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介质细胞流体/干细胞最了解:其与多态核核中性粒细胞相互作用的显著复杂性

Li-Tzu Wang^1,2,3, Wei Lee^4,5, Ko-Jiunn Liu⁶

¹Department of Obstetrics and Gynecology, National Taiwan University (NTU) Hospital and College of Medicine, NTU, Taipei, Taiwan.

Stem cells (Dayton, Ohio)

|February 4, 2024

概括

介酶体 stromal 细胞 (MSCs) 显著影响多态核中性粒细胞 (PMN) 功能,如亡,激活和迁移. 它们的效果因炎症状况和MSC来源而异,具有治疗潜力.

科学领域:

免疫学免疫学免疫学
细胞生物学细胞生物学
再生医学是一种再生医学.

背景情况:

多态核中性粒细胞 (PMNs) 是细菌感染的关键免疫细胞.
最近的研究揭示了PMN在健康和疾病中的更广泛作用.
介酶体 stromal 细胞 (MSCs) 具有再生和免疫调节的特性.

研究的目的:

分析PMN和MSC之间的复杂相互作用.
了解MSC如何调节PMN功能.
探索健康和疾病中这些相互作用的上下文依赖性.

主要方法:

审查有关PMN-MSC相互作用的现有文献.
分析MSC对PMN亡,激活 (CD11b表达,细胞),迁移,ROS产生和NETosis的影响.
在正常情况下与炎症条件下的相互作用的比较.
评估MSC源 (健康与患病的捐赠者) 的影响.

主要成果:

MSCs始终取消PMN的亡,除非PMN受到高度刺激.
MSC对PMN功能 (迁移,ROS,NETosis) 的影响取决于上下文.
在非炎症状态下,MSC增强PMN迁移和ROS生产.
在炎症状态下,MSCs减少PMN迁移,ROS产生和NETosis.
来自癌症患者的MSCs促进PMN透和NETosis,与健康的MSC不同.

结论:

MSC-PMN的互动是复杂的,高度特定于环境.
MSC属性和供体状态显著影响PMN反应.
了解这些动态对于开发基于MSC的PMN相关疾病疗法至关重要.

关键词:

在 CD11b 中,CD11b 是 CD11b 的第一个类型.网症 (NETosis) 是一种疾病.灭症 (apoptosis) 是一种死亡的过程.介酶体干细胞/干细胞移民移民迁移迁移发细胞症 (phagocytosis) 是一种致死细胞的发生.多态核中性粒细胞的多态核中性粒细胞.有活性氧物种的反应性氧物种.

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