根据性别和年龄,临床非功能性垂体神经内分泌瘤的不同瘤生长模式:一项纵向研究
S S Park1,2,3, H Kang3,4, Y H Kim5,6
1Department of Internal Medicine, Seoul National University College of Medicine, 101 Dae-hak ro, Seoul, 03080, Korea.
Journal of endocrinological investigation
|February 4, 2024
概括
临床非功能性垂体神经内分泌瘤 (CNF-PitNETs) 的瘤生长在50岁或更年轻的女性中较慢,而不是老年人和所有男性. 这些发现表明基于性别和年龄的CNF-PitNET的个性化监测.
科学领域:
- 内分泌学 在内分泌学.
- 在瘤学瘤学.
- 神经科学是一个神经科学.
背景情况:
- 临床非功能性垂体神经内分泌瘤 (CNF-PitNETs) 通常在没有干预的情况下进行监测.
- CNF-PitNETs的自然历史,特别是受性别和年龄影响的生长模式,尚不清楚.
研究的目的:
- 研究与患者的性别和年龄相关的CNF-PitNETs的生长模式.
- 为了确定男性和女性患者之间以及不同年龄组之间瘤生长动态的潜在差异.
主要方法:
- 一项纵向研究包括了431名在1997年至2021年期间接受治疗的CNF-PitNET患者.
- 患者接受了定期的成像随访,激素测试和视野测试,平均66个月.
- 分析了基于性别和年龄分层的瘤体积变化.
主要成果:
- 男性年龄较大,患有较大的瘤 (宏腺瘤) 的频率比女性高.
- 年度瘤体积增加在男性 (0.21厘米/年) 与女性 (0.04厘米/年) 相比显著更高.
- 50岁或更年轻的女性与所有年龄段的老年女性和男性相比,瘤生长显著放缓 (0.01厘米3/年).
结论:
- 在50岁或更年轻的女性中,CNF-PitNETs中的瘤生长明显较慢.
- 这些特定于性别和年龄的生长模式可以为患有CNF-PitNET的患者提供量身定制的监测策略.
- 个性化监测可以优化对垂体神经内分泌瘤的患者管理和资源分配.
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