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Updated: Jul 4, 2025

Author Spotlight: Evaluating Biophysical Assays for Characterizing PROTACS Ternary Complexes
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纳米平台和PROTAC接口的潜力,通过Ubiquitin-Proteasome系统实现目标蛋白质降解

Hanshu Xie1, Chao Zhang1

  • 1Stomatological Hospital, School of Stomatology, Southern Medical University, Guangzhou, 510280, China.

European journal of medicinal chemistry
|February 4, 2024
PubMed
概括

针对蛋白质溶解的嵌合体 (PROTACs) 提供高效的向蛋白质降解 (TPD),但面临交付挑战. 纳米医学增强了PROTAC的稳定性和传递力,用于治疗癌症等疾病.

关键词:
药物交付是药物交付的过程.一个纳米平台.这就是 PROTACs.有针对性的蛋白质降解降解.乌比奎丁蛋白酶体系统

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