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多基因风险得分通过家庭风险和控制的年轻人的认知和临床特征来调解功能结果

Alex G Segura¹, Elena de la Serna², Gisela Sugranyes²

¹Department of Clinical Foundations, Pharmacology Unit, University of Barcelona, Barcelona, Spain.

European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology

|February 4, 2024

概括

多基因风险评分 (PRS) 影响高风险年轻人精神疾病的早期迹象. 遗传学,认知和症状相互作用,为精神分裂症和双相情感障碍的个性化早期干预提供了洞察力.

科学领域:

精神病学是一个精神病学.
遗传学是一个遗传学.
发育神经科学的发展神经科学.

背景情况:

精神分裂症和双相情感障碍有共同的临床特征,特别是在患有疾病前症状的高危年轻人中.
严重的精神障碍是多基因的,但它们在表现前阶段的作用还没有得到充分研究.
了解对早期,下值症状的遗传影响对于预测疾病发作至关重要.

研究的目的:

调查多基因风险评分 (PRS) 对两年多的亚临床结果对精神分裂症和双相情感障碍家族高风险的年轻人的影响.
探索认知和临床特征在PRS和功能之间关系中的调解作用.
确定与从下值症状到精神障碍发作的连续性相关的遗传和表型因素.

主要方法:

使用PRS-CS方法在222名儿童和青少年 (患有精神分裂症/双相情感障碍的父母的后代和对照) 中计算了精神疾病,神经病症和认知的PRS.
采用线性混合效应模型来评估PRS与认知,症状严重程度和功能之间的关联.
进行调解分析,检查通过临床特征将PRS与功能结果联系起来的途径.

主要成果:

患有精神分裂症的父母的后代 (SZoff) 显示了精神分裂症的PRS升高.
在整个样本中,抑郁症,神经病症和认知特征的PRS与亚临床特征相关.
认知介绍了神经病症PRS对功能的影响;症状严重程度介绍了一般智力PRS对功能的影响.

结论:

这项研究强调了基因 (PRS),认知和临床特征在亚临床症状发展中的相互作用.
这些发现提供了关于从低于值症状过渡到严重精神障碍发作的机制的新证据.
结果表明,通过准遗传,认知和临床途径,有可能进行个性化的早期干预.

关键词:

认知认知是一种认知.家庭高风险家庭高风险运作运作运作多基因风险评分多基因风险评分.在值以下的症状.

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