在患有高胆固醇血症的患者中补充Monacolin K:临床试验的系统综述
E Liasi1, M Kantilafti2, E Hadjimbei1
1Department of Life Sciences, School of Sciences, European University Cyprus, Nicosia, Cyprus.
Semergen
|February 4, 2024
概括
红酵母大米 (RYR) 含有莫纳科林K,有效降低LDL和总胆固醇. 虽然通常是有益的,但由于潜在的不良影响,建议进行常规监测,即使在低剂量下也是如此.
科学领域:
- 心血管健康 心血管健康
- 药理学 药理学是指药理学的学科.
- 食补充剂 食补充剂
背景情况:
- 红酵米 (RYR) 是一种传统的中国产品,含有莫纳科林K,一种结构上与洛瓦斯塔丁相同的化合物.
- 莫纳科林K因其强大的降胆固醇特性而闻名,使其成为管理高胆固醇血症的兴趣对象.
研究的目的:
- 审查各种莫纳科林K剂量对血液胆固醇水平的疗效和安全性.
- 综合从临床试验和随机对照试验对莫纳科林K.综合发现.
主要方法:
- 对随机对照试验 (2012-2023) 的PubMed和Cochrane数据库进行系统搜索.
- 纳入标准:年龄大于18岁的参与者,使用莫纳科林K的干预,高胆固醇血症的结果 (总胆固醇或LDL胆固醇升高).
- 分析了12项高质量的随机对照试验,涉及769名参与者.
主要成果:
- 蒙纳林K补充剂,每天服用2mg至10mg的剂量,长达12周,显著降低了LDL和总胆固醇水平 (p<0.05).
- 所有包括的研究都表明对降低胆固醇有有益影响.
- 在12项研究中,有3项报告了不良副作用.
结论:
- 来自RYR的Monacolin K在降低血中胆固醇水平方面是有效的,通过各种剂量和持续时间降低血胆固醇水平.
- 莫纳科林K的安全性需要进一步调查,不论剂量如何,建议对患者进行常规监测.
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