心脂肪组织和心力衰竭,朋友还是敌人?
Dong-Hyuk Cho1, Seong-Mi Park1
1Division of Cardiology, Department of Internal Medicine, Korea University College of Medicine, Seoul, Korea.
Diabetes & metabolism journal
|February 4, 2024
概括
心脂肪组织 (EAT) 在心力衰竭 (HF) 风险和进展中起着关键作用. 研究表明,EAT体积和活性在HF表型之间有所不同,这表明潜在的治疗点.
科学领域:
- 心脏病学 心脏病学
- 代谢研究的研究.
- 生物医学成像学 生物医学成像学
背景情况:
- 肥胖是心力衰竭 (HF) 的一个公认的风险因素.
- 位于心脏周围的副心脏脂肪组织 (EAT) 越来越多地被研究其在HF中的作用.
- EAT在解剖学和功能上与心肌有关,影响心脏健康.
研究的目的:
- 探索心表脂肪组织 (EAT) 在不同心力衰竭 (HF) 现型中的病理生理作用.
- 审查目前对EAT对降低射出分数 (HFrEF) 和保持射出分数 (HFpEF) 的高温电流的贡献的理解.
- 讨论针对EAT在HF管理中的治疗潜力.
主要方法:
- 对有关EAT和HF的现有文献的审查.
- 对EAT评估的成像方式的分析.
- 对调查EAT在HFrEF和HFpEF病理生理学中的作用的研究进行审查.
主要成果:
- 在HFrEF中,EAT体积减少,这表明代谢储备有所减少.
- 在HFpEF中,增加的EAT与不良的生物标志物和血液动力学特征有关.
- 通过炎症性细胞因子分泌和改变脂肪酸释放,EAT有助于心肌重塑.
结论:
- 在HFrEF和HFpEF中,EAT起着独特的病理生理作用.
- 针对EAT的治疗策略,例如使用糖共传输体2抑制剂,显示出希望.
- 需要进一步的研究来澄清调节EAT活性对HF患者的临床益处.
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