关于3D打印儿童个性化药物的观点
Haixu Tong1, Juanhong Zhang2, Jing Ma1
1School of Pharmacy, and State Key Laboratory of Applied Organic Chemistry, Lanzhou 730000, China.
International journal of pharmaceutics
|February 4, 2024
概括
三维 (3D) 打印彻底改变了药物开发,使得药物可以被个性化地提供. 这项技术提供精确的儿科配方和复杂的组合疗法,为临床实施铺平了道路.
科学领域:
- 制药科学 制药科学
- 生物医学工程 生物医学工程
- 药物输送系统 药物输送系统
背景情况:
- 三维 (3D) 打印技术在制药开发中提供了显著的优势,特别是在个性化药物配方方面.
- 美国食品和药物管理局 (FDA) 对3D打印药物的批准加速了个性化药物输送系统的采用.
- 3D打印技术擅长满足儿科患者的特定剂量要求,并管理复杂的多药组合.
结论:
- 3D打印技术在推进儿科护理中个性化药物递送方面具有重大前景.
- 该综述为在临床儿科环境中实施3D打印提供了理论基础.
- 鼓励进一步的研究和临床试验,以充分实现3D打印儿童药物的潜力.
相关概念视频
02:50Combination Therapies and Personalized Medicine
Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
01:23Pharmacokinetics in Pediatric Patients: Overview and Drug Absorption
Understanding the physiological differences in the pediatric population is crucial for effective pharmacotherapy. Neonates, infants, and children exhibit significant variations in gastric pH, gastric emptying time, intestinal transit time, and biliary function. These variations profoundly affect oral drug absorption, necessitating a nuanced approach to pediatric dosing.Neonates present with a unique physiological profile, having a gastric pH greater than 4 and faster and more irregular gastric...
01:17Pharmacokinetics in Pediatric Patients: Drug Distribution
Drug distribution in the pediatric population exhibits unique challenges and considerations due to the physiological differences between children, particularly neonates and infants, and adults. A crucial aspect of pediatric pharmacology is understanding how these differences impact the pharmacokinetics of various drugs, necessitating age-specific dosing strategies to ensure efficacy and safety.Neonates and infants have a higher total body water content, ~75%–90% of their body weight, compared...