抗炎性细胞因子表达与阿皮卡粒瘤的临床数据之间的相关性
Renata C V Rodrigues1, Mariana T M Porpino2, Nilton Dessaune-Neto2
1Faculty of Dentistry and Postgraduate Program in Dentistry, Estácio de Sá University, Rio de Janeiro, Rio de Janeiro, Brazil; Faculty of Dentistry, Veiga de Almeida University, Rio de Janeiro, Rio de Janeiro, Brazil.
Journal of endodontics
|February 4, 2024
概括
在尖端颗粒瘤中观察到IFN-γ和TGF-β的高表达. 然而,只有IL-2和IL-5细胞因子水平与临床症状和根管治疗后的时间相关.
科学领域:
- 口腔病理学 口腔病理学
- 免疫学 免疫学 免疫学
- 牙周内科医院 牙周内科医院 牙周内科医院
背景情况:
- 角颗粒瘤是一种炎症性病变,在根管治疗后经常发生.
- CD4+ T 细胞分泌各种参与炎症过程的细胞因子.
- 了解角颗粒瘤中的细胞因子表达,可以提供对治疗结果的见解.
研究的目的:
- 为了评估关键的炎症性细胞因子 (IL-2,IL-5,IL-17,TGF-β,TNF-α,IFN-γ) 在角粒瘤中的表达.
- 为了将细胞因子表达与临床条件和根管治疗后的时间相关联.
主要方法:
- 对18个尖端颗粒瘤活检样本进行免疫组合化学分析.
- 使用光学显微镜评估细胞因子表达.
- 细胞因子水平,临床数据和治疗持续时间之间的相关性分析.
主要成果:
- 干扰素- (IFN-γ) 和转化生长因子-β (TGF-β) 显示出最高的表达水平.
- 与IFN-γ和TGF-β相比,IL-2的表达有显著的差异.
- 较低的IL-2表达与疼痛和鼻通道缺失相关,而较低的IL-5与前4年进行的治疗相关.
结论:
- 在尖端颗粒瘤中,IFN-γ和TGF-β的表达很高.
- IL-2和IL-5水平与临床表现和根管治疗以来的时间有关.
- 细胞因子概况可能为内牙治疗成功提供预后指标.
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