针对 chikungunya 病毒结构性和非结构性蛋白质的药物:一项审查
Mengke Wang1, Lidong Wang1, Ping Leng1
1College of Medical Technology, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, China.
International journal of biological macromolecules
|February 4, 2024
概括
Chikungunya 热 (CHIKF) 是一个越来越令人担忧的疾病. 本综述探讨了针对奇孔古尼亚病毒 (CHIKV) 蛋白质的抗病毒药物,以改善治疗和降低死亡率.
科学领域:
- 病毒学 病毒学
- 药物发现 药物发现 药物发现
- 传染性疾病 传染性疾病
背景情况:
- 奇孔古尼亚病毒 (CHIKV) 引起奇孔古尼亚发烧 (CHIKF),这是一个流行疾病,有定期爆发.
- 尽管批准了第一种疫苗 (Ixchiq),但疫苗接种率较低,需要采用替代治疗策略.
- 向病毒蛋白是开发有效抗CHIKV药物的关键策略.
研究的目的:
- 审查CHIKV的结构,功能和复制.
- 概述目前在抗CHIKV药物开发方面的进展.
- 在CHIKV非结构性和结构性蛋白质中识别潜在的治疗点.
主要方法:
- 关于CHIKV生物学和抗病毒药物开发的综合文献综述.
- 分析作为药物点的CHIKV非结构蛋白 (nsP1-nsP4) 和结构蛋白 (C,E3,E2,6K,E1).
- 评估当前和未来的药物开发战略.
主要成果:
- 奇克病毒的复制周期和蛋白质功能对于病毒病原发生至关重要.
- 一些CHIKV蛋白质,包括nsP1,nsP2,nsP3,nsP4,C,E3,E2,6K和E1,是抗病毒干预的可行目标.
- 目前的研究重点是开发小分子和其他药物来抑制这些病毒标.
结论:
- 开发有针对性的抗病毒疗法对于管理CHIKF疫情至关重要.
- 对CHIKV蛋白功能的进一步研究将加速新型抗CHIKV药物的发现.
- 针对多个病毒蛋白的组合疗法可能在治疗CHIKF时提供更高的疗效.
相关概念视频
01:26Targets for Drug Action: Overview
6.3K
Drugs target macromolecules to modify ongoing cellular processes. Primary drug targets include receptors, ion channels, transporters, and enzymes.
Receptors are either membrane-spanning or intracellular proteins, which upon binding a ligand, get activated and transmit the signal downstream to elicit a response. Drugs bind receptors, either mimicking the action of endogenous ligands or blocking the receptor activity to bring about a modified response. Nearly 35% of approved drugs target the G...
Receptors are either membrane-spanning or intracellular proteins, which upon binding a ligand, get activated and transmit the signal downstream to elicit a response. Drugs bind receptors, either mimicking the action of endogenous ligands or blocking the receptor activity to bring about a modified response. Nearly 35% of approved drugs target the G...
6.3K
00:56Viral Structure
62.3K
Viruses are extraordinarily diverse in shape and size, but they all have several structural features in common. All viruses have a core that contains a DNA- or RNA-based genome. The core is surrounded by a protective coat of proteins called the capsid. The capsid is composed of subunits called capsomeres. The capsid and genome-containing core are together known as the nucleocapsid.
62.3K