500名癌症患者中发生化疗诱导的神经病痛的发生率和危险因素:基于档案的观察性研究
Andreas A Argyriou1, Jordi Bruna2, Foteini Kalofonou3
1Neurological Department, "Agios Andreas" General Hospital of Patras, Patras, Greece.
Journal of the peripheral nervous system : JPNS
|February 4, 2024
概括
化疗诱导的神经病痛 (CINP) 影响了25.4%的癌症患者,糖尿病和特殊的化疗药物 (如酸) 的风险增加. 从CINP中恢复的可能性较小,与氧沙治疗.
科学领域:
- 在瘤学瘤学.
- 神经科学是一个神经科学.
- 药理学 药理学是指药理学的学科.
背景情况:
- 化疗诱导的神经病痛 (CINP) 是癌症护理的一个重大挑战.
- 了解其发生率和风险因素对于患者管理和治疗优化至关重要.
研究的目的:
- 为了确定接受化疗的癌症患者中CINP的发病率.
- 确定与CINP发展相关的关键风险因素.
主要方法:
- 追溯分析500名癌症患者的医疗档案.
- 使用PI-NRS和Douleur Neuropathique-4问卷进行的神经评估.
- 化学疗法诱导的周围神经毒性 (CIPN) 严重性的分级.
主要成果:
- 整体CINP发生率为25.4% (127/500名患者).
- 对于CINP的独立预测因素包括无并发的糖尿病和严重的慢性CIPN.
- 组合帕克利塔塞尔加上西斯,奥克萨利普拉丁和税与CINP风险有关,与帕克利塔塞尔/西斯相比,奥克萨利普拉丁显示显著降低风险.
- 增加急性oxaliplatin神经毒性严重程度与CINP有关.
- 接受过牛士利丁治疗的患者在化疗后从CINP改善的可能性较低.
结论:
- CINP的发生率与之前的研究一致,疼痛在治疗期间波动并且在治疗后下降.
- 没有并发症的糖尿病,帕克利塔塞尔/西斯普拉丁联合药物和严重的急性氧沙普拉丁神经毒性是CINP的主要危险因素.
- 与其他化疗相比,oxaliplatin治疗与CINP的恢复较差.
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