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Updated: Jul 4, 2025

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揭示阴茎时钟:分子时钟蛋白在人类阴茎洞腔组织中的表达

Ilter Alkan¹, Begum Durkut², Melike Ucak²

¹Department of Urology, School of Medicine, Yeditepe University, Istanbul, Turkey.

The world journal of men's health

|February 4, 2024

概括

核心分子钟基因在人类阴茎组织中表达,BMAL1在血管和光滑肌肉细胞中显示出显著的白天表达. 这表明分子钟在阴茎勃起生理学中的作用.

科学领域:

泌尿器科泌尿器科泌尿器科泌尿器科
时间生物学时间生物学
分子生物学分子生物学

背景情况:

分子时钟调节各种组织中的昼夜节律.
它在阴茎生理学,特别是阴茎勃起中的作用尚不清楚.

研究的目的:

研究人类阴茎洞穴组织中核心分子钟基因和蛋白质的表达.
为了确定它们的表达是否表现出昼夜变化.

主要方法:

在白天和晚上从健康的男性身上采集了洞体活检.
免疫组织化学和RT-qPCR用于分析BMAL1,CLOCK,PER1-3和CRY1-2的蛋白质和基因表达.

主要成果:

在血管内皮细胞 (VEC) 和光滑肌细胞 (SMC) 中检测到核心分子钟蛋白.
在白天,BMAL1的核表达率较高,在晚上则下降.
同时,CRY1和PER3表达也显示了分别在VEC和SMC的夜间显著下降.

结论:

核心分子钟基因在人类阴茎组织中得到表达.
像BMAL1这样的蛋白质存在于洞穴体的VEC和SMC中.
分子时钟机制可能在阴茎勃起的生理学中发挥重要作用.

关键词:

循环时钟是循环的时间表.循环节律是循环节律的节奏.内皮,血管内皮,血管内皮.阴茎阴茎是一个阴茎.

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The biological clock is involved in many aspects of regulating complex physiology in all animals. It was in 1935 when German zoologists, Hans Kalmus and Erwin Bünning, discovered the existence of circadian rhythm in Drosophila melanogaster. However, the internal molecular mechanisms behind the circadian clock remained a mystery until 1984, when Jeffrey C. Hall, Michael Rosbash, and Michael W. Young discovered the expression of the Per gene oscillating over a 24-hour cycle. In subsequent...