这是日本第一例Mycobacterium插入肺部疾病的病例
Asuka Yamaguchi1, Naohisa Urabe1, Nozomi Tokita1
1Department of Respiratory Medicine, Toho University Omori Medical Center, Japan.
Internal medicine (Tokyo, Japan)
|February 4, 2024
概括
本案例研究详细介绍了一名患有Mycobacterium插孔肺病 (M.插孔肺病-PD) 的患者,该患者在接受阿齐思罗素,利芬素和乙ambutol治疗后显著改善. 它强调了日本首次报告的M. interjectum-PD病例.
科学领域:
- 肺部病理学 肺部病理学
- 传染性疾病 传染性疾病
- 微生物学 微生物学
背景情况:
- 非结核性菌根性肺病 (NTM-PD) 是一个越来越令人担忧的问题.
- 微细菌插孔肺病 (M.interjectum-PD) 是罕见的,报告的病例有限.
- 准确的诊断和有效的治疗策略对于M. interjectum-PD至关重要.
研究的目的:
- 报告在日本诊断和治疗的第一个M. interjectum-PD病例.
- 描述M. interjectum-PD.的临床表现和诊断发现.
- 评估针对M. interjectum-PD.特定抗生素治疗方案的疗效.
主要方法:
- 一名69岁的妇女被调查,怀疑NTM-PD有6年的病史.
- 进行高分辨率胸部计算机断层扫描 (CT) 来评估肺部异常.
- 分析了支气管洗和唾液培养,以鉴定菌根菌.
- 治疗开始时使用阿兹罗密辛 (AZM),里芬素 (RFP) 和乙胺醇 (EB).
主要成果:
- 胸部CT显示了支气管切除和右下叶中叶和左下叶的结节.
- 支气管洗和唾液培养证实了Mycobacterium interjectum的存在.
- 在用AZM,RFP和EB治疗后,唾液培养物转换为负的.
- 胸部CT的放射性发现显示了随后的改善.
结论:
- 这一案例是日本首次有记录的M. interjectum-PD病例.
- 与阿齐思罗密辛,利芬素和乙胺醇的联合治疗在治疗M. interjectum-PD时被证明是有效的.
- 早期诊断和适当的抗微生物治疗对于管理M. interjectum-PD至关重要.
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