ProFun:一种用于对寄生虫原生动物基因进行功能丰富分析的Web服务器
Po-Jung Huang1, Yi-Chen Weng2, Kuo-Yang Huang3
1Department of Biomedical Sciences, Chang Gung University, Taoyuan, Taiwan; Genomic Medicine Research Core Laboratory, Chang Gung Memorial Hospital, Linkou, Taiwan.
概括
ProFun是一个新的网络工具,用于对寄生虫原生动物的功能丰富分析 (FEA). 这个平台简化了对热带病原体的基因表达数据的解释,有助于研究.
科学领域:
- 生物信息学是一种生物信息学.
- 寄生虫学的寄生虫学
- 基因组学就是基因组学.
背景情况:
- 功能丰富分析 (FEA) 对于解释多omics数据至关重要.
- 现有的FEA工具主要支持人类和模型生物,缺乏对寄生虫原生动物的支持.
- 寄生原生动物是重要的热带病原体,需要专门的分析工具.
研究的目的:
- 开发ProFun,一个用户友好的,基于网络的平台,用于原生动物的功能丰富分析.
- 促进对寄生虫原生动物进行多学科的比较研究.
- 为研究界提供一个可扩展和可访问的工具.
主要方法:
- ProFun使用Docker,ShinyProxy和R Shiny构建了一个可扩展的Web服务.
- 它集成了视觉分析,自定义脚本和注释包.
- 该平台提供了三个模块:基因重叠,过度代表性分析 (ORA) 和基因组丰富分析 (GSEA) 针对40种原生动物物种.
主要成果:
- ProFun提供了一个Web服务器,可以轻松地对差异表达基因进行功能丰富分析.
- 用户可以输入基因ID,自定义参数,并通过单击获取结果.
- 直观的界面生成准备发布的图表,用于识别生物事件和潜在目标.
结论:
- ProFun是第一个用于对寄生虫原生动物基因功能丰富分析的网络应用程序.
- 它支持FEA,并允许在复杂的实验设计中对结果进行比较.
- 对于研究人员来说,ProFun是免费在线访问的.
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