TiO2@CoOx异构结构通过原子层沉积的精确设计,用于协同效应的化动力瘤疗法
Wen Liu1,2, Runrun Shao1, Lingyun Guo1,3
1Basic Medical College, Shanxi Medical University, Taiyuan, 030001, P. R. China.
Advanced science (Weinheim, Baden-Wurttemberg, Germany)
|February 4, 2024
概括
这项研究通过使用原子层沉积来创建TiO2和CoOx异质连接来增强癌症的声动疗法 (SDT). 这种协同方法改善了瘤细胞的杀死,并将SDT与化学动力学疗法 (CDT) 结合起来,以更好地抑制瘤.
科学领域:
- 材料科学 材料科学 材料科学
- 纳米技术纳米技术
- 生物医学工程 生物医学工程
背景情况:
- 声动疗法 (SDT) 使用超声波激活声敏剂,产生反应性氧物种 (ROS) 用于瘤细胞破坏.
- 二氧化 (TiO2) 在SDT中表现出有限的疗效,原因是ROS生成低,抗瘤活性不足.
研究的目的:
- 为了提高基于TiO2的声动力疗法的效率.
- 开发一种结合SDT和化学动力学疗法 (CDT) 的协同癌症治疗方法.
主要方法:
- 使用原子层沉积 (ALD) 制造一个多孔的TiO2/CoOx异质连接.
- 对异质连接的特性及其在超声波照射下产生ROS的性能的描述.
- 评估CDT和SDT在瘤微环境中的协同抗瘤作用.
主要成果:
- ALD能够精确地将CoOx纳米粒子加载到TiO2中,优化界面和能量带结构以增强SDT.
- 该CoOx成分促进了级联反应 (H2O2→O2→·O2−),缓解瘤缺氧并促进ROS的产生.
- 结合化学动力学和声动力学治疗 (CDT/SDT) 有效地抑制了瘤的生长.
结论:
- 开发的TiO2/CoOx异构连接显著提高了SDT的疗效.
- 原子层沉积为工程催化瘤治疗剂提供了一种精确的方法.
- 协同作用的CDT/SDT为改善癌症治疗提供了一个有前途的战略.
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