相关实验视频

Updated: Jul 4, 2025

In Silico Identification and Characterization of circRNAs During Host-Pathogen Interactions

In Silico Identification and Characterization of circRNAs During Host-Pathogen Interactions

Published on: October 21, 2022

对circRNAs与参与癌症病原发生的信号通路之间的相关性进行治疗洞察

Raed Obaid Saleh¹, Sulieman Ibraheem Shelash Al-Hawary², Saade Abdalkareem Jasim³

¹Department of Medical Laboratory Techniques, Al-Maarif University College, Al-Anbar, Iraq.

Medical oncology (Northwood, London, England)

|February 4, 2024

概括

循环RNAs (circRNAs) 在细胞功能和疾病中起着至关重要的作用. 本综述探讨了它们在癌症中的作用,强调了它们作为诊断生物标志物和治疗点的潜力.

科学领域:

分子生物学分子生物学
遗传学是一个遗传学.
在瘤学瘤学.

背景情况:

循环RNAs (circRNAs) 是非编码的RNA分子,由前传递 RNA的反向拼接形成.
循环RNAs执行关键的生物功能,包括作为miRNA海绵,调节蛋白质活性,并作为翻译模板.
调节失调的circRNA表达与各种疾病,特别是癌症有关,原因是维护平衡的分子通路被破坏.

研究的目的:

审查circRNAs在癌症中的生物和致癌作用.
要突出circRNAs在信号转导通路中的参与.
探索circRNAs作为癌症早期检测和预后的新生物标志物的潜力.

主要方法:

关于circRNA生物发生,功能和癌症中的作用研究的文献综述.
对circRNA参与关键癌症相关分子通路的分析.
对circRNAs作为癌症生物标志物的现有证据的评估.

主要成果:

循环RNA表现出多种功能,影响基因调节和蛋白质相互作用.
异常的circRNA表达是许多癌症的标志,影响细胞过程.
循环RNA在各种与癌症相关的信号传导途径中发挥作用.

结论:

循环RNAs是癌症发展和进展的关键参与者.
作为癌症早期诊断和预后的生物标志物,circRNAs具有显著的前景.
向circRNAs是癌症治疗的潜在治疗策略.

关键词:

癌症癌症癌症癌症循环RNAs 是一个循环RNAs.没有编码的RNAs.信号通道的信号通道.

更多相关视频

Analysis of Combinatorial miRNA Treatments to Regulate Cell Cycle and Angiogenesis

Analysis of Combinatorial miRNA Treatments to Regulate Cell Cycle and Angiogenesis

Published on: March 30, 2019

CRISPR Gene Editing Tool for MicroRNA Cluster Network Analysis

CRISPR Gene Editing Tool for MicroRNA Cluster Network Analysis

Published on: April 25, 2022

相关概念视频

Interactions Between Signaling Pathways

Interactions Between Signaling Pathways

Signaling cascades usually lack linearity. Multiple pathways interact and regulate one another, allowing cells to integrate and respond to diverse environmental stimuli.
Convergence and divergence, and cross-talk between signaling pathways
Two distinct signaling pathways can converge on a single functional unit, which may either be a single protein or a complex of proteins. The response is either functionally distinct or synergistic between the two pathways but different from the response...

Non-Canonical Wnt Signaling Pathways

Non-Canonical Wnt Signaling Pathways

Wnt is a zygotic effect gene that is expressed during very early embryonic development. It regulates various processes in animals starting from early development through the adult stage, such as organogenesis in the embryo and maintenance of neuronal and blood stem cells. Wnt proteins can induce a wide variety of intracellular pathways depending upon the specific abilities of different Wnt ligands to form a complex with shared and cognate receptors in the presence of different co-receptors. The...

mTOR Signaling and Cancer Progression

mTOR Signaling and Cancer Progression

The mammalian target of rapamycin or mTOR protein was discovered in 1994 due to its direct interaction with rapamycin. The protein gets its name from a yeast homolog called TOR. The mTOR protein complex in mammalian cells plays a major role in balancing anabolic processes such as the synthesis of proteins, lipids, and nucleotides and catabolic processes, such as autophagy in response to environmental cues, such as availability of nutrients and growth factors.
The mTOR pathway or the...

Canonical Wnt Signaling Pathway

Canonical Wnt Signaling Pathway

The gene encoding the main signaling molecules of the Wnt signaling pathways (the Wnt proteins) was discovered almost four decades ago by Nüsslein-Volhard and Wieschaus. They identified and originally named the gene "wingless" (wg) after a phenotype discovered during their landmark genetic screen in Drosophila for body pattern defects. At around the same time, another researcher named Harold Varmus found that a murine tumor virus activates the mammalian wg homolog, Int-1, which...

lncRNA - Long Non-coding RNAs

lncRNA - Long Non-coding RNAs

In humans, more than 80% of the genome gets transcribed. However, only around 2% of the genome codes for proteins. The remaining part produces non-coding RNAs which includes ribosomal RNAs, transfer RNAs, telomerase RNAs, and regulatory RNAs, among other types. A large number of regulatory non-coding RNAs have been classified into two groups depending upon their length – small non-coding RNAs, such as microRNA, which are less than 200 nucleotides in length, and long non-coding RNA...

Targeted Cancer Therapies

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...