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Updated: Jul 4, 2025

Intramucosal Inoculation of Squamous Cell Carcinoma Cells in Mice for Tumor Immune Profiling and Treatment Response Assessment
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用免疫疗法治疗的头部和部状细胞癌患者的瘤突变负担可预测性:系统性审查和元分析

Juan P Rodrigo1,2, Mario Sánchez-Canteli3,4, María Otero-Rosales1,2

  • 1Department of Otolaryngology, Hospital Universitario Central de Asturias and Instituto de Investigación Sanitaria del Principado de Asturias (ISPA), Instituto Universitario de Oncología del Principado de Asturias, University of Oviedo, 33011, Oviedo, Spain.

Journal of translational medicine
|February 4, 2024
PubMed
概括

高瘤突变负担 (TMB) 预测在头部和部状细胞癌 (HNSCC) 中对免疫检查点抑制剂 (ICI) 的反应更好. 这一发现为改善HNSCC患者选择和临床益处提供了预测性生物标志物.

关键词:
头部和部状细胞癌瘤免疫检查点抑制剂 免疫检查点抑制剂进行元分析分析.瘤的突变负担

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相关概念视频

Tumor Immunotherapy01:27

Tumor Immunotherapy

Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
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