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库辛病的性别相关差异:系统性审查和元分析
Basel F Alqeeq1, Mohammed Ayyad2, Waseem J Almadhoun1
1From the Faculty of Medicine, Islamic University of Gaza, Gaza, Palestine.
Annals of Saudi medicine
|February 5, 2024
概括
患有库辛病的男性更年轻,症状更严重,如骨质疏松症和低血量症. 这种内分泌疾病在表现和诊断方面表现出明显的性别特异.
科学领域:
- 内分泌学 在内分泌学.
- 内部医学 内部医学
- 临床研究 临床研究
背景情况:
- 库辛病是一种罕见的内分泌疾病.
- 了解性别差异对于有效管理至关重要.
研究的目的:
- 检查库辛病呈现和临床特征的性别特异性差异.
- 综合现有的关于库辛病性别影响的证据.
主要方法:
- 对已发表的文献进行了元分析.
- 在主要数据库 (Medline,Embase,CENTRAL,Scopus) 进行系统的文献搜索.
- 包括9项涉及1047名被诊断患有库辛病的患者的研究.
主要成果:
- 男性患者呈现的年龄较小 (平均差异 -5.43年;P<.00001).
- 在男性中,骨质疏松症 (RR 1.75; P<.0001) 和低血 (RR 1.66; P=.0002) 的患病率更高.
- 男人呈现较高的负MRI发现率 (RR 1.53;P=.002);糖尿病或脂质失调患病率没有性别差异.
结论:
- 库辛病在男性中表现得更严重.
- 与女性相比,男性面临的诊断挑战更大.
- 性别特异性差异需要量身定制的临床方法.
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