Marc Vandemeulebroecke1, Dieter A Häring1, Eva Hua2

  • 1Novartis Pharma AG, Basel, Switzerland.

PubMed
概括

结合两项临床试验的数据,有效地证明了药物在二次终点上的疗效. 这种方法需要仔细规划和监管讨论,才能成功开发药物.

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Bonferroni Test01:10

Bonferroni Test

The Bonferroni test is a statistical test named after Carlo Emilio Bonferroni, an Italian mathematician best known for Bonferroni inequalities. This statistical test is a type of multiple comparison test to determine which means are different than the rest. Bonferroni test can minimize the Type 1 error by reducing the significance level alpha, which otherwise increases with sample pairs.
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Statistical Hypothesis Testing

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Null and Alternative Hypotheses

The actual hypothesis testing begins by considering two hypotheses. They are termed  the null hypothesis and the alternative hypothesis. These hypotheses contain opposing viewpoints.
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Multiple Comparison Tests01:13

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Multiple comparison test, abbreviated as MCT, is a post hoc analysis generally performed after comparing multiple samples with one or more tests. An MCT will help identify a significantly different sample among multiple samples or a factor among multiple factors.
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Testing a Claim about Population Proportion

A complete procedure for testing a claim about a population proportion is provided here.
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