[末期慢性功能衰竭患者的垂体疾病]
T N Markova1, E V Kosova2, N K Mishchenko3
1Moscow State University of Medicine and Dentistry Named after A.I.Evdokimov; City Clinical Hospital №52.
Problemy endokrinologii
|February 5, 2024
概括
慢性病 (CKD) 破坏了垂体激素水平,增加了益生素,LH和FSH. 置换疗法可以使一些激素正常化,而移植通常会纠正这些内分泌功能障碍,改善患者的结果.
科学领域:
- 内分泌学 在内分泌学.
- 腎臟病學 (nephrology) 是一種醫學專業.
- 恒常状态 (Homeostasis) 是一种恒常状态.
背景情况:
- 功能障碍显著影响平衡和重要物质的新陈代谢,包括垂体激素.
- 慢性病 (CKD) 与内分泌功能的复杂变化有关,特别是影响垂体腺.
研究的目的:
- 为提供CKD患者下垂体功能障碍的概述.
- 探索导致CKD的荷尔蒙变化背后的病原遗传机制.
- 在末期慢性病患者接受替代疗法 (RRT) 和移植后评估垂体激素水平.
主要方法:
- 对CKD下垂体功能障碍现有文献的综述.
- 分析CKD患者的荷尔蒙特征,包括RRT患者.
- 移植前后激素水平的比较.
主要成果:
- 慢性结核病会增加益乳素,黄素化激素 (LH) 和卵泡刺激激素 (FSH).
- 在CKD中,生长激素 (GH),IGF-1,TSH,ACTH和血管压素水平可能是正常的或升高的.
- RRT部分正常化GH,IGF-1和TSH,但不正常化益生素,LH或FSH. 可能会降低ACTH和血管压素.
- 移植通常会纠正脑下垂体荷尔蒙失衡.
结论:
- 下垂体功能障碍是CKD的常见并发症,具有特定的激素水平变化.
- 脏移植提供了部分激素纠正,而脏移植提供了更全面的恢复.
- 在CKD患者中解决荷尔蒙失衡可能会改善临床结果和生活质量.
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