相关实验视频

Updated: Jul 4, 2025

An Optimized Hemagglutination Inhibition HI Assay to Quantify Influenza-specific Antibody Titers

An Optimized Hemagglutination Inhibition HI Assay to Quantify Influenza-specific Antibody Titers

Published on: December 1, 2017

在墨西哥用不同疫苗免疫接种后,对SARS-CoV-2变异的免疫反应

Erika Garay¹, Sean P J Whelan^2,3, Rebecca M DuBois⁴

¹Departamento de Genética del Desarrollo y Fisiología Molecular, Instituto de Biotecnología, Universidad Nacional Autónoma de México, Cuernavaca, Morelos, Mexico.

Epidemiology and infection

|February 5, 2024

概括

在成年人中分析了对SARS-CoV-2疫苗 (ChAdOx1-S,Sputnik V,BNT162b2) 的抗体反应. 之前的感染增强了疫苗的免疫性,而强剂增加了中和活性.

科学领域:

免疫学免疫学免疫学
疫苗学疫苗学疫苗学
病毒学病毒学

背景情况:

关于高并发症率的发展中国家的SARS-CoV-2疫苗免疫性存在有限的数据.
了解抗体反应对于优化不同人群的疫苗接种策略至关重要.

研究的目的:

为了评估对同类SARS-CoV-2疫苗接种方案 (ChAdOx1-S,Sputnik V,BNT162b2) 的抗体反应和助推效应.
评估之前的SARS-CoV-2感染对疫苗免疫性和对变种的中和能力的影响.
在接种疫苗后4个月内调查抗体标位衰变.

主要方法:

与酶相关的免疫吸收试验 (ELISA) 和伪病毒中和试验 (PNA) 用于测量抗体标位.
参与者包括中年成人,在接种疫苗之前对SARS-CoV-2尖端蛋白具有血清阳性或血清阴性.
接种了同源的疫苗方案和一次ChAdOx1-S强剂,并进行了4个月的随访.

主要成果:

这三种疫苗 (ChAdOx1-S,Sputnik V,BNT162b2) 在之前感染了SARS-CoV-2的个人中显示出优异的IgG抗RBD和中和反应,对抗阿尔法和三角形变异.
一次ChAdOx1-S增强剂量在未感染和预暴露的个体中显著增加了中和活性.
与其他人相比,ChAdOx1-S疫苗在未感染的受试者中诱导了较弱的抗体反应.
抗体标位在4个月内下降,在没有感染的个体中,抗体的中和能力较低.

结论:

之前的SARS-CoV-2感染显著提高了同源的COVID-19疫苗的免疫性.
增强剂量有效增加对SARS-CoV-2变种的中和活性.
在血清流行率高的人群中,异种疫苗策略可能是有益的.
疫苗的选择和考虑先前的感染状况对于有效的SARS-CoV-2控制很重要.

关键词:

在 COVID-19 疫情中,关于COVID-19疫苗的使用情况墨西哥墨西哥墨西哥墨西哥在SARS-CoV-2变种中.混合免疫的混合免疫力血清转换是一种血清转换.

更多相关视频

Author Spotlight: A Pseudotype Virus System for Assessing Omicron Subvariants and Neutralizing Antibodies in SARS-CoV-2 Research

Author Spotlight: A Pseudotype Virus System for Assessing Omicron Subvariants and Neutralizing Antibodies in SARS-CoV-2 Research

Published on: September 8, 2023

Dynamic Monitoring of Seroconversion using a Multianalyte Immunobead Assay for Covid-19

Dynamic Monitoring of Seroconversion using a Multianalyte Immunobead Assay for Covid-19

Published on: February 16, 2022

相关概念视频

Vaccinations

Vaccinations

Cross-reactivity

Cross-reactivity

Immunological Memory

Immunological Memory

Immunological memory, a pivotal pillar of the adaptive immune system, is responsible for the body's ability to remember and respond more swiftly and effectively to previously encountered pathogens. This remarkable feature is what makes vaccines so effective in preventing diseases.
What is Immunological Memory?
Immunological memory is an integral function of the immune system that allows it to recognize and react more rapidly and effectively to pathogens previously encountered. This feature...

Cells of the Adaptive Immune Response

Cells of the Adaptive Immune Response

The T and B lymphocytes of the adaptive immune system develop from common lymphoid progenitor cells in the bone marrow. These progenitors give rise to precursors that eventually develop into both T and B lymphocytes. As these precursors mature, they gain the ability to detect and respond to foreign antigens in the body, a process known as immunocompetence. Additionally, these precursors acquire self-tolerance, a process that ensures they do not react to self-antigens. This intricate system...