在加拿大安大略省,第一次发作状态的发生率和危险因素
R Grace Couper1, Tresah C Antaya1,2, Piotr Wilk2,3,4,5
1Neuroepidemiology Research Unit, Department of Clinical Neurological Sciences, Western University, London, ON, Canada.
概括
在安大略省,第一次发作状态 (SE) 的发生率为每10万人/年3.5. 高龄和诸如痴呆症和中风等疾病增加了SE的风险.
科学领域:
- 神经学 神经学
- 流行病学 流行病学
- 公共卫生 公共卫生
背景情况:
- 状态 (SE) 是一种关键的神经紧急情况.
- 缺乏准确的发病率数据和首次发病SE的风险因素.
- 这项研究解决了加拿大大量人口中的这些知识差距.
研究的目的:
- 为了确定在加拿大安大略省首次发病SE的发病率.
- 识别与第一集SE.相关的社会人口统计和健康相关的风险因素.
主要方法:
- 基于人口的回顾性队列研究,使用链接的卫生行政数据.
- 包括2006年加拿大人口普查长形式问卷中居住在安大略省 (18-105岁) 的个人,没有以前的SE历史.
- 考克斯比例危险回归分析以估计三年内SE风险.
主要成果:
- 分析了1,301,700名参与者的队列,其中140人经历了第一集的SE.
- 第一次SE发病的发病率计算为每10万人/年3.5人.
- 显著的危险因素包括年龄,酒精/药物滥用,脑瘤,慢性脏病,痴呆症,糖尿病,/发作和中风.
结论:
- 在安大略省,首发性SE的发病率估计为每10万人/年3.5.
- 晚年和特定的并发性疾病与首发性SE的风险增加有显著的关联.
- 调查结果强调,需要针对有风险人群制定有针对性的预防和管理策略.
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