在患有eosinophilic胃肠炎的患者中,长期预后及其相关预测因素
Kai-Wen Li1, Ge-Chong Ruan1, Shuang Liu2
1Department of Gastroenterology, Chinese Academy of Medical Sciences and Peking Union Medical College Hospital, Beijing 100730, China.
World journal of gastroenterology
|February 5, 2024
概括
性胃肠炎 (EGE) 复发是常见的,年龄较小,疾病持续时间较长,吐是危险因素. 较高的BMI和IgE水平可以防止EGE患者的复发.
科学领域:
- 胃肠病学 胃肠病学
- 免疫学 免疫学 免疫学
- 内部医学 内部医学
背景情况:
- 酸性胃肠炎 (EGE) 是一种慢性胃肠道疾病,其特征是酸性透.
- 葡萄糖皮质类药物是主要的治疗方法,但疾病复发和依赖是重大挑战.
- 关于EGE预后和复发风险因素的数据有限.
研究的目的:
- 描述EGE的临床特征.
- 通过长期随访,识别疾病复发的潜在预测因素.
主要方法:
- 55名EGE患者的回顾性队列研究 (2013-2022年).
- 分析临床记录,包括人口统计,症状和治疗.
- 卡普兰-梅尔曲线和日志等级测试用于评估无复发生存 (RFS) 风险因素.
主要成果:
- 中位发病年龄为38岁,女性略有占主导地位.
- 常见的症状包括腹痛 (89.1%),腹 (61.8%),吐 (47.3%).
- 较年轻的年龄 (<40岁),较长的疾病持续时间 (>3.5个月),吐和葡萄糖皮质激素治疗与更高的复发风险有关. 较高的BMI (>24 kg/m2) 和较高的总IgE (>300 KU/L) 是具有保护性的.
结论:
- 较年轻的发作,长期的疾病过程,吐和葡萄糖皮质激素治疗是EGE复发的危险因素.
- 较高的BMI和基线总IgE水平似乎是EGE患者复发的保护因素.
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