艾滋病毒相关的淋巴瘤:双刃剑
Reema Singh1, Jyotsna Kapoor1, Nisha Panwar1
1Department of Hematology and Bone Marrow Transplant Unit, Rajiv Gandhi Cancer Institute and Research Centre, Sector 5, Rohini, Delhi, 110085 India.
概括
艾滋病毒 (人类免疫缺陷病毒) 感染者面临淋巴瘤风险增加. 这项研究表明,艾滋病毒相关淋巴瘤的预后是可以接受的,10年生存率约为79%,即使是晚期疾病.
科学领域:
- 在瘤学瘤学.
- 传染性疾病 传染性疾病
- 血液学 血液学 血液学
背景情况:
- 与普通人群相比,艾滋病毒 (人类免疫缺陷病毒) 感染者患淋巴瘤的风险更高.
- 这种高风险甚至在高度活跃的抗逆转录病毒疗法 (HAART) 时代仍然存在.
研究的目的:
- 以回顾分析HIV相关淋巴瘤患者的结果.
- 为了评估这个队列的整体反应率 (ORR),整体存活率 (OS) 和无事件存活率 (EFS).
主要方法:
- 在2012年1月至2022年10月期间,对23名艾滋病毒相关淋巴瘤患者进行了回顾性分析.
- 统计分析包括Kaplan-Meier的生存率和chi-square的疾病反应因子.
- 需要至少6个月的随访时间.
主要成果:
- 大多数患者 (57.9%) 呈现4期疾病.
- 扩散性大B细胞淋巴瘤 (DLBCL) 是最常见的,60%的人在一线化疗后实现完全缓解 (CR).
- 在最后一次随访时,78.95%的患者还活着,10年的生存率和无进展生存率 (PFS) 为78.95%±11%.
结论:
- 与艾滋病毒相关的淋巴瘤显示出可接受的预后.
- 尽管表现较晚,CD4计数较低,并发抗逆转录病毒疗法 (ART),但可以实现有利的结果.
- 密集化疗有助于治疗的积极结果.
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