在一个资源有限的国家,CMV感染后异构造血造干细胞移植在一个资源有限的国家
Noor Yuhyi Sulaiman1, Nur Adila Anuar1, Normala Arshad1
1Department of Medicine, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia.
概括
在马来西亚,细胞巨乳病毒 (CMV) 感染影响35.7%的血造干细胞移植 (HSCT) 后患者. 偶同移植和移植与宿主疾病 (GVHD) 会增加CMV感染的风险.
科学领域:
- 传染性疾病 传染性疾病
- 血液学 血液学 血液学
- 移植医学 移植医学
背景情况:
- 细胞巨乳病毒 (CMV) 感染是所有原性造血干细胞移植 (HSCT) 患者的发病和死亡的重要原因.
- 马来西亚的CMV感染血清流行率很高,因此需要有关移植后结果的当地数据.
研究的目的:
- 为了确定CMV感染在马来西亚患者在异性HSCT后的流行率.
- 在这个患者群体中识别与CMV感染相关的风险因素.
主要方法:
- 在2008年至2020年间,对112名接受异性HSCT的患者进行了回顾性分析.
- 在HSCT后至少100天的随访,以评估CMV感染发病率.
- 风险因素的统计分析,包括移植类型,捐赠者/患者血清状况,GVHD和人口统计.
主要成果:
- 在40名 (35.7%) 患者中诊断出CMV感染,中位数发病时间为HSCT后40天.
- 哈普洛相同的HSCT和移植对宿主疾病 (GVHD) 的存在被确定为CMV感染的显著风险因素.
- 在CMV感染的患者中观察到较低中位生存时间的趋势,尽管在统计学上不显著.
结论:
- 马来西亚的CMV感染率与其他亚洲国家相比,高于西方国家.
- 警监测CMV感染至关重要,特别是在接受平分异性HSCT和急性GVHD的患者中.
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