相关实验视频
Updated: Jul 4, 2025

Direct Reprogramming of Mouse Fibroblasts into Melanocytes
Published on: August 27, 2021
放射治疗可能会加剧抗编程细胞死亡1治疗诱导的白风:一个病例报告
Chengqian Chen1, Qihang Chang1, Bo Wang2
1Institute of Photomedicine Shanghai Skin Disease Hospital School of Medicine Tongji University Shanghai China.
编程细胞死亡1 (PD-1) 抑制剂治疗与化学放射治疗相结合,可能导致皮肤副作用,如白风. 在一个直肠癌病例中,这些副作用与治疗的积极反应相关.
科学领域:
- 在瘤学瘤学.
- 免疫学 免疫学 免疫学
- 皮肤病学 皮肤病学
背景情况:
- 编程细胞死亡1 (PD-1) 抑制剂与化学放射疗法 (CRT) 结合,是有前途的癌症治疗方法.
- 与免疫相关的不良事件 (irAEs),包括皮肤疾病如白风,是PD-1抑制剂的常见情况,可能导致治疗停止.
研究的目的:
- 在患有直肠癌的老年患者中报告PD-1抑制剂相关的白风病例.
- 探索皮肤IRAE,RT和癌症患者的临床结果之间的关系.
主要方法:
- 一位患有第3b期直肠癌的老年患者的病例报告,接受PD-1抑制剂和化疗放射治疗.
- 在RT后观察白风的发展和恶化.
- 在停用PD-1抑制剂后监测irAEs和直肠癌反应.
主要成果:
- 患者患有PD-1抑制剂相关的白风,在RT后扩大.
- 在停止PD-1抑制剂治疗后,白和的状况有所改善.
- 在随访期间,直肠癌实现了临床完整反应,没有复发或转移.
结论:
- 来自PD-1抑制剂的皮肤不良事件可能与有利的临床反应相关.
- 与RT加重的皮肤IRAE表明显著的免疫激活,可能有助于瘤回归.
- 仔细管理irAEs对于优化癌症免疫治疗结果至关重要.
更多相关视频
11:04An In-House-Built and Light-Emitting-Diode-Based Photodynamic Therapy Device for Enhancing Verteporfin Cytotoxicity in a 2D Cell Culture Model
Published on: January 13, 2023
05:39Author Spotlight: Radiotherapy and Clonogenic Assays for Advancing Cancer Research and Personalized Medicine
Published on: April 5, 2024
相关概念视频
Tumor Immunotherapy
Cancer Therapies
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
Targeted Cancer Therapies
There are several types of targeted therapies against...
Combination Therapies and Personalized Medicine
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...