根据患者报告的问卷,为前列腺癌进行支臂治疗后,性和勃起功能发生变化
László Gesztesi1, Zsuzsa S Kocsis2, Kliton Jorgo1,3
1National Institute of Oncology, Centre of Radiotherapy, Budapest, Hungary.
Prostate cancer
|February 5, 2024
概括
在局部前列腺癌患者中,高剂量率胸腔疗法 (HDRBT) 提供了比低剂量率胸腔疗法 (LDRBT) 更好的性功能恢复. 与LDRBT不同的是,HDRBT在没有激素治疗的患者中显示出持久的性功能改善.
科学领域:
- 在瘤学瘤学.
- 辐射瘤学 辐射瘤学
- 泌尿器科 泌尿器科 泌尿器科 泌尿器科
背景情况:
- 支臂疗法是局部性前列腺癌的常见治疗方法.
- 使用高剂量率支臂治疗 (HDRBT) 和低剂量率支臂治疗 (LDRBT) 两种方法.
- 性副作用显著影响患者治疗后的生活质量.
研究的目的:
- 为了比较HDRBT与LDRBT对性功能和幸福感的副作用.
- 为了评估患者报告的局部性前列腺癌治疗HDRBT或LDRBT的结果.
- 为了评估激素治疗状态对勃拉基疗法后性功能结果的影响.
主要方法:
- 前性研究 (PROMOBRA) 比较单一LDR (145 Gy) 和单一HDR (19/21 Gy) 的治疗方法.
- 123名患者接受LDRBT,117名患者接受局部低风险/低中期风险前列腺癌的HDRBT.
- 患者报告的结果测量 (PROM) 问卷 (EORTC QLQ-PR-25,IIEF,IIEF-5) 在治疗前和多个随访点进行,长达2年.
主要成果:
- 在没有激素治疗的患者中,LDRBT导致勃起功能,高潮,性欲和满足感的显著而持久的下降.
- 在未经激素治疗的患者中,高强度激素转移治疗导致性功能暂时下降,并观察到恢复.
- 与LDRBT相比,在多个时间点中,接受激素治疗的患者在HDRBT时表现出更好的性高潮功能和性欲.
结论:
- 在局部前列腺癌治疗中,HDRBT和LDRBT都是安全的.
- 与LDRBT相比,HDRBT在未经激素治疗的患者中对保持性功能具有更有利的概况.
- 高强度激素转移治疗可能提供更好的性功能结果,特别是在没有激素的前列腺癌患者中.
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