从佐洛皮转换为莱博雷克桑的失眠患者:一项多中心的开放性研究,评估了下一剂量转换方法以治疗失眠的药理疗法
Maha Ahmad1, James Kelly1, C Brendan Montano2
1Clinilabs Drug Development Corporation, New York, NY, USA.
Sleep medicine: X
|February 5, 2024
概括
大多数成年人成功地从佐尔皮酸盐 (ZOL) 转换为针对失眠的勒博雷克桑 (LEM). 与ZOL相比,Lemborexant的耐受性很好,并且改善了睡眠维持.
科学领域:
- 睡眠医学 睡眠医学
- 药理学 药理学是指药理学的学科.
- 临床试验 临床试验
背景情况:
- 很少有研究评估了失眠药物之间的现实世界的过渡.
- 皮酸 (Zolpidem tartrate,简称ZOL) 是一种常见的短期治疗失眠的方法.
- 像莱博雷克桑 (LEM) 这样的双素受体抗剂 (DORAs) 为失眠管理提供了不同的机制.
研究的目的:
- 评估直接将患者从ZOL转移到LEM的策略.
- 为了评估ZOL停止后LEM的疗效和耐受性.
- 为了比较成年失眠患者的LEM和ZOL之间的睡眠维持.
主要方法:
- 一项随机的,开放的,多中心的研究 (研究312) 招募了53名患有失眠障碍的成年人使用ZOL.
- 参与者在2周的治疗阶段从ZOL过渡到5毫克或10毫克的LEM.
- 12周的延长阶段允许继续使用LEM和剂量调整.
主要成果:
- 81.1%的受试者从ZOL成功过渡到LEM.
- 与ZOL相比,使用LEM与醒来后恢复入睡的能力有所改善 (71.7%与49.1%相比).
- 大多数LEM治疗出现的不良事件都是轻微的.
结论:
- 从ZOL直接过渡到LEM是一个可行的策略来管理失眠.
- 伦博雷克桑 (Lemborexant) 在改善睡眠维持方面表现出良好的耐受性和有效性.
- 这项研究支持LEM作为从ZOL过渡的患者的替代方案.
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