维生素B6周转率预测了2型糖尿病患者的长期死亡风险
Fangqi Li1, Xiangliang Liu1, Lingling Zhao1
1Cancer Center, The First Hospital of Jilin University, Changchun, China.
Current developments in nutrition
|February 5, 2024
概括
维生素B6的更高的循环量,由4-氧酸 (4-PA) 与氧醇5'-酸 (PLP) 的比例表明,与2型糖尿病 (T2DM) 患者的死亡风险增加有关. 这个比率可能有助于预测T2DM管理中的结果.
科学领域:
- 生物化学 生物化学
- 内分泌学 在内分泌学.
- 公共卫生 公共卫生
背景情况:
- 炎症会影响维生素B6的新陈代谢,增加其吸收和分解.
- 维生素B6的转化量增加,以4-皮里多克酸 (4-PA) /皮里多克萨尔5'-酸 (PLP) 的比率来衡量,与一般人群的死亡率有关.
研究的目的:
- 调查维生素B6周转率 (4-PA/PLP比率) 与2型糖尿病患者的长期死亡率之间的关联.
- 评估4-PA/PLP比率作为T2DM预后标记物的潜力.
主要方法:
- 使用NHANES数据 (2005-2010年) 进行的前性队列研究,并对死亡率进行了到2019年12月的随访.
- 在2074名T2DM患者中,通过高性能液体色谱测量了血4-PA和PLP度.
- 使用了COX回归和受限制的立方支线模型,对混因子进行调整.
主要成果:
- 在T2DM患者中,较高的4-PA/PLP比率和死亡风险之间发现了显著的正相关性 (HR最高与最低四分位数:5.03;在完全调整后P<0.001).
- 这种关联在各种敏感性和子组分析中仍然显著,包括因特定原因死亡率.
- 在4-PA/PLP比率和全因死亡率之间观察到正相关性.
结论:
- 增加维生素B6的循环是T2DM患者长期死亡的独立风险因素.
- 4-PA/PLP比率显示出作为一种用于管理T2DM的实际预后生物标志物具有前途.
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