耳功能障碍是正常听力和轻度听力损失认知衰退的早期生物标志物
Vicente Medel1,2, Paul H Delano1,3,4,5, Chama Belkhiria1
1Departamento de Neurociencia Facultad de Medicina Universidad de Chile Santiago Chile.
Alzheimer's & dementia (Amsterdam, Netherlands)
|February 5, 2024
概括
扭曲产物耳声排放 (DPOAEs) 可以检测与老年人认知衰退相关的耳功能障碍,在评估痴呆风险方面表现优于传统的听力测试. 这为早期识别神经退行提供了一种新的方法.
科学领域:
- 耳鼻喉科 耳鼻喉科 耳鼻喉科
- 神经科学是一个神经科学.
- 老年学是一门学科.
背景情况:
- 与年龄相关的听力损失是认知能力下降的重要危险因素.
- 传统的听力测量不足以估计正常或轻度听力损失的个体的痴呆风险.
- 扭曲产物耳声排放 (DPOAEs) 为评估听觉功能提供了一个敏感的,客观的衡量标准.
研究的目的:
- 评估DPOAEs作为估计正常或轻度听力损失的老年人认知衰退风险的工具.
- 为了比较DPOAEs与传统听力测试在预测认知衰退方面的有效性.
- 研究耳功能障碍与神经退行症标志物之间的关联.
主要方法:
- 对94名64岁以上的参与者进行了神经心理评估.
- 大脑磁共振成像 (MRI) 用于评估大脑缩.
- 审计分析包括DPOAE测量和常规听力测量.
主要成果:
- 通过DPOAEs识别的耳功能障碍与临床痴呆症评分盒总和 (CDR-SoB) 分数相关.
- DPOAEs,但不是听力测量,揭示了耳功能障碍和大脑缩之间的联系.
- 这些发现在正常 (<25 dB) 和轻度 (25-40 dB) 听力损失的参与者中具有意义.
结论:
- DPOAEs显示出作为一种非侵入性方法来检测老年人的神经退行和认知衰退的承诺.
- 这一客观措施可以促进对认知障碍的早期干预策略.
- DPOAEs可以作为与听力损失相关的潜在神经变化的早期指标.
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