阿尔茨海默氏病中的线粒:从2007年到2022年的图书统计分析
Hongqi Wang1,2, Xiaodong Yan2, Yiming Zhang2
1Department of Neurology, Peking University Aerospace School of Clinical Medicine, Aerospace Center Hospital, Beijing, China.
Journal of Alzheimer's disease reports
|February 5, 2024
概括
图书统计分析显示,食是阿尔茨海默病 (AD) 研究中的新兴机制,对相关药物和点越来越感兴趣. 这项研究绘制了16年来阿尔茨海默病的线粒的研究趋势和边界.
科学领域:
- 图书统计学 图书统计学
- 神经科学是一个神经科学.
- 药理学 药理学是指药理学的学科.
背景情况:
- 在阿尔茨海默氏症 (AD) 中的线粒研究是通过图书统计分析未被充分探索的.
- 了解线粒在阿尔茨海默病中的作用对于开发新的治疗策略至关重要.
研究的目的:
- 为了提供一个全面的图书统计概述,在AD. mitophagy研究.
- 确定该领域的研究趋势,前沿和关键参与者.
- 绘制目标,药物,临床试验和与阿尔茨海默病中线粒细胞衰变相关的疾病之间的关系.
主要方法:
- 从Web of Science核心集合 (2007-2022) 中对5,146篇出版物进行了图书统计分析.
- 提取和评估文献统计数据,目标,药物,临床试验和疾病关联.
- 识别多产的作者,期刊,关键词和趋势研究领域.
主要成果:
- 在有关线粒和AD的出版物中,持续16年的上升趋势.
- 美国在出版物方面处于领先地位;阿尔茨海默病杂志是最多产的.
- 确定了关键作者,趋势基因 (PINK1,帕金),关键词 (胰岛素,衰老,陶病) 和药物 (黄素,黑激素).
- 线粒体功能障碍是疾病集群的一个中心主题.
结论:
- 线粒是一种新兴的分子机制,也是阿尔茨海默病的潜在治疗点.
- 这项文献计量研究开创了目标药物-临床试验-疾病相关性的整合.
- 为研究人员和临床医生研究AD机制和治疗提供了宝贵的见解.
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