合允许哺乳动物强大的氧化还原昼夜节律,尽管异质和噪声
Marta Del Olmo1, Anton Kalashnikov1, Christoph Schmal1
1Institute for Theoretical Biology - Humboldt Universität zu Berlin and Charité Universitätsmedizin Berlin, Philippstraße 13, 10115 Berlin, Germany.
Heliyon
|February 5, 2024
概括
噪音和细胞变异性可以破坏昼夜时钟. 然而,这些细胞振荡器的合可以恢复强大的日常节奏,证明细胞如何克服内部随机性以实现同步的生理功能.
科学领域:
- * 生物化学和分子生物学
- * 系统生物学 系统生物学
- * * 时间生物学
背景情况:
- * 循环时钟是细胞内固有的计时器,调节日常生理和行为节奏.
- *哺乳动物的昼夜节律是由转录-翻译反循环 (TTFL) 和氧化还原反应产生的.
- * TTFL和氧化还原机制在单细胞水平上表现出固有的静态性和异质性.
研究的目的:
- * 调查噪音和异质性如何影响昼夜节律中的氧化还原振荡器.
- * 探索合的随机氧化还原振荡器的新兴特性.
- * 了解氧化还原振荡器和TTFL在昼夜节律生成中的相互作用.
主要方法:
- * 简化了氧化还原振荡的动力模型,将其转化为带有"扭曲"的振荡幅相振荡器.
- * 引入高斯噪声来模拟随机性和异质性.
- *分析了振荡器之间的合和与TTFL模型集成的影响.
主要成果:
- * 噪音和异质性本身就会导致振荡器的快速脱同步.
- *噪音振荡器之间的合导致了强大的同步,振幅扩展和通过"扭曲"进行周期调整.
- *将氧化还原振荡器与TTFL模型集成,可以增强同步和振幅,并微调周期.
结论:
- * 合对于建立同步的昼夜节律至关重要,尽管细胞内噪声和异质性.
- *氧化还原振荡器中的"扭曲"机制有助于周期调节.
- * 这些发现揭示了昼夜系统如何实现对随机性强度的稳定性.
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