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在患有状细胞疾病的儿童中,轻微的身体异常包括部形图案和部尺寸:一个横截面分析研究
Raghavendra M Shetty1,2,3, Aditi Pashine4, Sunaina Shetty5
1Department of Clinical Sciences, College of Dentistry, Ajman University, Ajman, United Arab Emirates.
Heliyon
|February 5, 2024
概括
患有状细胞疾病 (SCD) 的儿童表现出明显的 palatal rugae 模式和尺寸,可能作为轻微的物理异常. 这些发现突显了SCD患者发育不良的形和改变的 palatal 形态,有助于早期诊断.
科学领域:
- 头骨面部形态学 头骨面部形态学
- 遗传学和遗传性疾病
- 儿科牙科 儿科牙科
背景情况:
- 状细胞病 (SCD) 是一种常见的遗传性血红蛋白病.
- SCD可能导致生长延迟,影响骨和面发育.
- palatal rugae 模式被认为是 palatal 发育的关键调节者.
研究的目的:
- 为了研究SCD儿童的口腔形态,形图案和尺寸.
- 为了比较患有SCD的儿童与健康对照之间的这些特征.
- 评估 palatal rugae 作为 SCD 的轻微物理异常 (MPA) 的潜力.
主要方法:
- 一项横截面病例控制研究,涉及50名SCD儿童和50名健康儿童 (年龄10-18岁).
- 牙印记和造被用来测量 palatal rugae 的长度,形状和图案.
- 记录了口腔尺寸 (宽度,高度,面积) 和粗的测量.
主要成果:
- 与对照组相比,患有SCD的儿童的口腔和碎片总数较少 (p < 0.05).
- 在SCD组中,口腔深度显著增加.
- 在SCD组中,面积显著减少.
结论:
- 在患有SCD的儿童中,独特的 palatal rugae 模式和尺寸可以作为潜在的 MPA.
- 患有SCD的患者表现出发达不足的 palatal rugae,口腔深,窄,小.
- 这些发现可能有助于在早期的SCD诊断和通过正牙治疗预防 malocclusion.
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