前列腺癌患者的尿道外前列腺手术:基于人群的并发症和死亡率的比较分析
Michele Marchioni1,2, Giulia Primiceri2, Alessandro Veccia3
1Laboratory of Biostatistics, Department of Medical, Oral and Biotechnological Sciences, "G. d'Annunzio" University of Chieti, Chieti, Italy.
Asian journal of urology
|February 5, 2024
概括
经过尿道式前列腺手术的前列腺癌 (PCa) 患者与良性前列腺激增症 (BPH) 患者相比,并发症和死亡率相似. 诊断似乎不会影响手术结果或技术的有效性.
科学领域:
- 泌尿器科 泌尿器科 泌尿器科 泌尿器科
- 手术瘤学手术瘤学
- 医疗保健服务研究 医疗服务研究
背景情况:
- 下泌尿道症状 (LUTS) 在前列腺癌 (PCa) 和良性前列腺增生 (BPH) 两种情况下都很常见.
- 一些PCa患者可能被错误诊断和治疗BPH,影响手术结果.
- 了解PCa与BPH对跨尿道前列腺手术结果的影响对于患者管理至关重要.
研究的目的:
- 为了比较PCa和BPH患者进行过尿道式前列腺手术的外科结果.
- 评估PCa与BPH对并发症和死亡率的影响.
- 评估PCa诊断是否会影响不同外科手术技术的结果.
主要方法:
- 来自美国外科医生学院国家外科质量改善计划数据库 (2011-2016) 的34,542名患者的回顾性分析.
- 患者根据术后诊断进行了分层:PCa (2008) 与BPH.
- 后勤回归模型分析了术后发病率和死亡率的预测因素,并进行了诊断和手术技术的相互作用测试.
主要成果:
- 在PCa和BPH患者之间的术后并发症没有统计学上显著的差异 (OR 0.9,95% CI 0.7-1.1;p=0.252).
- 观察到类似的术后死亡率,心血管事件,输血和长时间住院.
- 在PCa诊断和手术技术结果之间没有发现显著的相互作用.
结论:
- 与BPH相比,PCa诊断不会导致经尿道前列腺手术后的术后发病率或死亡率增加.
- 手术技术的结果并没有受到PCa诊断的显著影响.
- 目前通过尿道进行的前列腺手术方法似乎对PCa和BPH患者都是安全有效的.
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