血清血栓激素水平可以预测败血症患者的死亡率?
Van Tri Nguyen1,2, Hong Ngoc Nguyen-Phan3, Bui Bao Hoang3
1Department of Internal Medicine, Hue University of Medicine and Pharmacy, Hue University, Hue City, Vietnam.
Medical archives (Sarajevo, Bosnia and Herzegovina)
|February 5, 2024
概括
溶性血栓模块素 (sTM) 水平在败血症和败血性休克患者中显著升高,特别是那些致命的患者. 这一发现表明sTM是预测败血症严重程度和死亡率的可靠生物标志物.
科学领域:
- 生物化学 生物化学
- 关键护理医学 关键护理医学
- 病理生理学 病理生理学
背景情况:
- 血栓模块素 (TM) 是内皮细胞上的一种糖蛋白,参与各种生化途径.
- 溶性血栓模块素 (sTM) 是一种在生物流体中主要存在的形式.
- TM在蛋白C系统和败血症发病过程中发挥着关键作用.
研究的目的:
- 在败血症和败血性休克患者中确定血清sTM水平.
- 评估sTM水平与住院生存结果之间的关系.
- 为了验证sTM作为败血症死亡率的预测指标.
主要方法:
- 63名败血症/败血性休克患者的前性观察性研究.
- 用于诊断的败血症3标准.
- 在败血症,败血性休克,生存和致命组之间测量和比较血清sTM水平.
主要成果:
- 与败血症和生存组相比,败血症休克和致命组的sTM水平显著更高.
- sTM显示出强大的死亡预测能力 (AUC=0.803),与SOFA相比,优于APACHE II和DIC得分.
- 在败血症休克和致命组中观察到乳酸和肌氨酸的升高.
结论:
- 血清sTM是预测败血症严重程度和死亡率的可靠生物标志物.
- 升高的sTM水平与败血症患者的死亡风险增加有关.
- sTM可以帮助临床决策危急性败血症患者.
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