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自我报告的症状的性别相关的差异在pheochromocytomas和paragangliomas的诊断时
Stefanie Parisien-La Salle1, Isabelle Bourdeau1
1Division of Endocrinology, Department of Medicine, Research Center, Centre Hospitalier de l'Université de Montréal (CHUM), Montreal, Quebec H2X 0A9, Canada.
性别差异影响染细胞瘤和偏角细胞瘤的呈现. 妇女更频繁地报告头痛,而男性显示出更高的糖尿病率,根据瘤类型和分泌状态的变化.
科学领域:
- 内分泌学 在内分泌学.
- 在瘤学瘤学.
- 临床医学 临床医学
背景情况:
- 生物性别影响疾病的表现和严重程度.
- 乳色细胞瘤和偏角细胞瘤 (PPGLs) 是一种罕见的神经内分泌瘤,具有潜在的多种临床表现.
- 了解PPGL的性别差异对于准确的诊断和管理至关重要.
研究的目的:
- 在诊断时检查染细胞瘤和偏角细胞瘤 (PPGLs) 的体征和症状的性别相关差异.
- 根据瘤位置和分泌状态来确定性别是否影响PPGLs的临床表现.
主要方法:
- 在1995年至2022年期间诊断出PPGL的385名患者的回顾性审查.
- 分析呈现的迹象和症状,按性别和瘤类型分层 (头部和部副质瘤,胸腔腹部副质瘤,体红细胞瘤).
- 在男性和女性之间比较症状的发病率,包括头痛,糖尿病,隔膜症和心.
主要成果:
- 与男性相比,女性 (60.8%) 在所有瘤类型和分泌状态 (P = .007) 中更频繁出现头痛 (39.2%).
- 男人患糖尿病的发病率更高,特别是在乳色细胞瘤 (PHEOs) 和分泌瘤 (P = .039和P = .0035,分别).
- 在女性中,非分泌PPGL与增加的头痛 (P = .0002),透光 (P = .0454) 和心 (P = .0057) 相关.
结论:
- 在PPGLs的临床表现中存在显著的基于性别的差异.
- 女性通常会经历头痛,而男性更容易患上糖尿病,在不同瘤亚型和分泌状态中观察到特定的模式.
- 这些差异可能归因于上腺素受体敏感度,症状报告,荷尔蒙影响和血管活性的变化.
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