血液粘度在急性伤寒发烧中的变化:一个横截面研究
1Department of Biology, College of Science, Baghdad University, Baghdad, Iraq.
Journal of medicine and life
|February 5, 2024
概括
伤寒患者由于血蛋白增加和血细胞减少而表现出血粘度 (BV) 变化. 监测BV可能有助于检测心血管并发症高风险伤寒患者.
科学领域:
- 传染性疾病 传染性疾病
- 血液学 血液学 血液学
- 临床病理学 临床病理学
背景情况:
- 由沙门氏菌Typhi引起的伤寒热 (TF) 是通过受污染的来源传播的系统性感染.
- 血液粘度 (BV) 受血红蛋白和急性相反应物等因素的影响,在感染和炎症期间经常发生变化.
- 传染病中的炎症反应可以提高血蛋白水平,影响血液类风湿学.
研究的目的:
- 在被诊断患有急性伤寒热 (TF) 的患者中调查血液粘度 (BV) 的变化.
- 在TF患者和健康个体之间比较BV和相关的炎症参数.
主要方法:
- 采用了横截面研究设计.
- 招募了55名急性TF患者和38名健康对照.
- 测量了血液粘度和关键炎症标志物,包括血总蛋白和血红素,并在组之间进行了比较.
主要成果:
- 与健康对照组相比,伤寒患者的血细胞计数显著减少 (p=0.001).
- 与对照组 (7.035±1.44 g/L,p=0.03) 相比,TF患者的血总蛋白水平明显升高 (10.79±1.05 g/L).
- 在TF患者中观察到血液粘度增加的趋势,尽管血红素水平没有显著差异 (p=0.07).
结论:
- 伤寒患者血液粘度升高可能与血总蛋白质水平增加有关.
- 增加TF中的BV可能会增加出现并发症的风险.
- 监测伤寒患者的血粘度,特别是高风险患者,可能有助于早期发现心血管并发症.
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