导致SARS-CoV-2肝和肝损伤的分子机制
Jorge Quarleri1, M Victoria Delpino2
1Instituto de Investigaciones Biomédicas en Retrovirus y Sida (INBIRS), Universidad de Buenos Aires (UBA), Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Buenos Aires 1121, Argentina. quarleri@fmed.uba.ar.
World journal of hepatology
|February 5, 2024
概括
严重急性呼吸道综合征冠状病毒-2 (SARS-CoV-2) 可以感染肝脏,通过直接的病毒效应和炎症引起损伤. 了解这种肝性是管理COVID-19患者肝脏并发症的关键.
科学领域:
- 肝病学 肝病学是一种肝病学.
- 病毒学 病毒学
- 免疫学 免疫学 免疫学
背景情况:
- 严重急性呼吸系统综合征冠状病毒-2 (SARS-CoV-2) 主要影响呼吸系统,但也影响肺外器官,包括肝脏.
- 在肝脏组织,血管,内皮细胞和肝细胞中检测到病毒RNA和粒子,证实了SARS-CoV-2在肝脏中的存在.
研究的目的:
- 探索SARS-CoV-2引起的肝损伤 (COVID-19相关的肝损伤) 的机制.
- 突出显示SARS-CoV-2在肝细胞上的肝和直接细胞病变影响的作用.
- 讨论COVID-19中导致肝损伤的因素.
主要方法:
- 对SARS-CoV-2和肝脏参与的现有文献和案例研究的审查.
- 在肝脏组织中检测病毒的分析 (病毒RNA,in situ杂交,电子显微镜).
- 讨论分子机制,包括受体表达,炎症,缺氧和免疫反应.
主要成果:
- SARS-CoV-2 可以感染肝细胞和内皮细胞,导致直接的细胞病变效应.
- 多种因素导致肝损伤,包括直接的病毒影响,炎症,免疫反应和药物毒性.
- SARS-CoV-2的肝炎是COVID-19相关的肝损伤的一个重要因素,在慢性肝病患者中有可能出现渐进性胆固醇病.
结论:
- SARS-CoV-2 感染可以通过直接的病毒效应和间接机制导致严重的肝损伤.
- 了解分子通路,包括ACE2受体表达和免疫反应,是管理COVID-19肝脏并发症的关键.
- 需要进一步的研究来充分阐明SARS-CoV-2与肝脏之间的复杂相互作用,特别是在患有肝脏疾病的患者中.
更多相关视频
11:34A Competent Hepatocyte Model Examining Hepatitis B Virus Entry through Sodium Taurocholate Cotransporting Polypeptide as a Therapeutic Target
Published on: May 10, 2022
2.2K
08:41Live Imaging and Quantification of Viral Infection in K18 hACE2 Transgenic Mice Using Reporter-Expressing Recombinant SARS-CoV-2
Published on: November 5, 2021
2.8K
相关概念视频
01:24Liver Regeneration
3.3K
The liver is an important organ in vertebrates that plays an essential role in metabolism. It is also responsible for storing and redistributing nutrients such as carbohydrates, fats, and vitamins in the body. Additionally, the liver releases bile salts which are critical for digesting food and eliminating toxic metabolites from the body.
Cells of Liver
The liver comprises four major types of cells— hepatocytes, stellate, Kupffer, and sinusoidal endothelial cells. The hepatocytes are...
Cells of Liver
The liver comprises four major types of cells— hepatocytes, stellate, Kupffer, and sinusoidal endothelial cells. The hepatocytes are...
3.3K
02:50Conjugated Proteins
18.3K
Simple proteins and protein complexes contain only amino acids. In contrast, many other proteins, called conjugated proteins, covalently bond with non-protein moieties.
Nucleoproteins are protein complexes that contain nucleic acids, categorized as deoxyribonucleoproteins (DNPs) or ribonucleoproteins (RNPs) respectively. The nucleosome is a typical example of a DNP where nuclear DNA is associated with histone proteins. The major antigen for the Covid-19 virus SARS-CoV is an RNP that is critical...
Nucleoproteins are protein complexes that contain nucleic acids, categorized as deoxyribonucleoproteins (DNPs) or ribonucleoproteins (RNPs) respectively. The nucleosome is a typical example of a DNP where nuclear DNA is associated with histone proteins. The major antigen for the Covid-19 virus SARS-CoV is an RNP that is critical...
18.3K