在存在背景选择的情况下,精确推断人口史
Trevor Cousins1, Daniel Tabin1, Nick Patterson1,2
1Department of Human Evolutionary Biology, Harvard University, Cambridge, MA, USA.
bioRxiv : the preprint server for biology
|February 5, 2024
概括
这项研究引入了PSMC+,一种新方法,在推断人口数量随时间变化时考虑自然选择. 这提高了准确性,并揭示了对人口历史和遗传差异的新见解.
科学领域:
- 人口遗传学 人口遗传学
- 基因组学就是基因组学.
- 进化生物学是进化的生物学.
背景情况:
- 当前的人口推断方法假定中性进化,忽视自然选择的影响.
- 背景选择 (BGS) 显著影响物种间的遗传变异模式.
- 链接选择损害了有效人口大小 (N(t)) 推断的准确性.
研究的目的:
- 开发一种改进的推断人口历史的方法,其中包括自然选择.
- 为了提高有效人口大小 (N(t)) 估计的准确性.
- 调查背景选择对人口推理的影响.
主要方法:
- 引入了PSMC+ (对式顺序马科维亚凝聚体加),这是PSMC算法的扩展.
- 同模型的人口历史和自然选择明确地.
- 基准的PSMC+使用了将BGS纳入的前期时间模拟.
主要成果:
- 与现有方法相比,PSMC+在有效人口大小推断方面表现出更好的准确性.
- 使用人类BGS地图进行的分析揭示了推断N(t) 的实质性变化.
- 在大猿的X染色体与自体体上的N(t) 的推断显示出显著的,特定于物种的波动,突出了未经纠正的选择的作用.
结论:
- PSMC+提供了一种更准确的方法来推断人口历史,通过考虑链接选择.
- 自然选择,特别是BGS,显著影响人口推断,必须考虑.
- 未经纠正的选择可能会导致灵长类动物的性别染色体和自体之间观察到的遗传差异.
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