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Myeloid Innate Signaling Pathway Regulation by MALT1 Paracaspase Activity
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依赖于Arid1a的正规BAF复合物抑制炎症程序,以驱动高效的生殖中心B细胞反应

Ajay Abraham1,2, Daniela Samaniego-Castruita1, Jillian Paladino1

  • 1Department of Cell and Developmental Biology, Northwestern University, Chicago, Illinois, USA, 60611.

Research square
|February 5, 2024
PubMed
概括

由Arid1a调节的正规BAF (cBAF) 综合体,对于维持生殖中心 (GC) B细胞反应和高亲和抗体产生至关重要. 它的缺失导致GC崩和由于炎症导致免疫力受损.

关键词:
B 细胞 B 细胞 B 细胞在BAF复杂的 BAF复杂.表观遗传学 在表观遗传学中,表观遗传学是指表观遗传学.生殖中心的生殖中心.炎症 炎症是一种炎症.

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