莱维体病中的冷漠及其对随着时间的推移对功能障碍的影响
Carolyn W Zhu1,2,3, Hillel T Grossman2,3, Gregory A Elder2,3,4
1Brookdale Department of Geriatrics and Palliative Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, United States.
Frontiers in neurology
|February 5, 2024
概括
无动于衷显著影响莱维体病 (LBD) 的日常功能,导致随着时间的推移更大的损伤和更快的衰退. 早期评估冷漠对于管理LBD患者的功能衰退至关重要.
科学领域:
- 神经科学是一个神经科学.
- 神经学 神经学
- 老年学是一门学科.
背景情况:
- 漠不关心是神经退行性疾病的常见症状,如阿尔茨海默氏症和前性痴呆症.
- 它对利维体病 (LBD) 的功能结果的影响仍然不够描述.
- 这项研究调查了大量LBD队列中的冷漠的流行率和功能后果.
研究的目的:
- 为了确定无动于衷的流行率和持久性,在一个全国性的Lewy体病患者队列中.
- 分析冷漠对功能状态随时间推移的纵向影响.
- 了解LBD中冷漠,认知状态和帕金森症之间的关系.
主要方法:
- 一组676名轻度认知障碍或痴呆症的参与者和初级LBD诊断被跟踪平均3.4年.
- 漠不关心被分为四个类型:从来没有,间歇性,持续性和始终无动于衷.
- 使用功能评估问卷 (FAQ) 评估功能障碍,并记录了痴呆症严重程度和帕金森症.
主要成果:
- 无动于衷的患病率从基线的54.4%增加到第四年65.5%,其中77%的人在某个时候经历过无动于衷.
- 与从未无动于衷的人相比,在有间歇性/持续性和总是无动于衷的个人资料的参与者中观察到更高的FAQ分数.
- 功能衰退 (FAQ) 的年率在始终冷漠的个体中明显更快.
结论:
- 漠不关心是高度普遍和持久的勒维体病患者的认知障碍.
- 无动于衷独立地与更大的功能障碍和加速的功能衰退有关.
- 针对性评估和冷漠的管理对于改善LBD的功能结果至关重要.
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