伦瓦提尼布与辛蒂利马布加上跨动脉化学栓塞结合,作为先进肝细胞癌的第一线治疗
Sha-Sha Sun1, Xiao-Di Guo1, Wen-Dong Li1
1Department of Oncology, Capital Medical University Affiliated Beijing Ditan Hospital, Beijing 100015, China.
World journal of clinical cases
|February 5, 2024
概括
用伦瓦提尼布,辛蒂利马布和跨动脉化学栓塞 (TACE) 进行的第一线三重疗法显示,在晚期肝细胞癌 (HCC) 患者中,有希望的生存结果和可管理的副作用.
科学领域:
- 肝胆道癌症 肝胆道癌症
- 医学瘤学 医学瘤学
- 免疫治疗是一种免疫疗法.
背景情况:
- 组合疗法为肝细胞癌 (HCC) 提供了比单一疗法更好的治疗结果.
- 对于先进的HCC,对一线三重疗法 (伦瓦替尼布+辛蒂利马布+TACE) 的研究有限.
研究的目的:
- 评估一线三重治疗先进HCC的安全性和有效性.
- 评估整体存活率,客观反应率,疾病控制率和不良事件.
主要方法:
- 对40名先进的HCC患者进行了回顾性分析,这些患者接受了伦瓦提尼布,辛提利马布和TACE的治疗.
- 伦瓦提尼布每天,辛蒂利马布每3周一次,TACE每4-6周一次,根据需要.
- 主要终点:整体存活率 (OS);次要终点:目标反应率 (ORR),疾病控制率 (DCR),不良事件.
主要成果:
- 随访时间中位数为8.5个月.
- 3个月,6个月和12个月的OS率:100%,88.5%和22.5%分别.
- 在ORR45%,DCR90%. 常见的不良事件发生在76%的人身上 (级别3: 15%,级别4: 2.5%).
结论:
- 三重疗法 (伦瓦替尼布,辛蒂利马布,TACE) 在晚期HCC中显示出有前途的疗效.
- 组合疗法显示了可管理的安全性.
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