传染性支气管炎病毒马萨诸塞州和德尔马瓦 (DMV/1639) 基因型在产母中的比较致病性
Muhammad Farooq1, Reham M Abd-Elsalam1,2, Natalya Ratcliff1
1Health Research Innovation Center, Faculty of Veterinary Medicine, University of Calgary, Calgary, AB, Canada.
Frontiers in veterinary science
|February 5, 2024
概括
德尔马瓦DMV/1639传染性支气管炎病毒 (IBV) 基因型导致的卵产量大幅下降和严重损伤. 马萨诸塞 (Mass) IBV基因型显示出较少的严重影响,突出显示家禽的不同致病性.
科学领域:
- 兽医病毒学 兽医病毒学
- 禽类病理学 禽类病理学
- 鸟类传染病 鸟类传染病
背景情况:
- 传染性支气管炎 (IB) 是一种由传染性支气管炎病毒 (IBV) 引起的的传染性病毒性疾病.
- 新出现的IBV基因型对全球家禽产业构成了持续的挑战,尽管疫苗接种广泛.
- 了解基因型特异性致病性对于层层地有效的疾病管理至关重要.
研究的目的:
- 为了比较两种不同的IBV基因型的致病性:马萨诸塞州 (Mass) 和德尔马瓦 DMV/1639.9.
- 评估这些基因型对特定无病原体的产卵母产卵,病毒脱落,组织病变和亡的影响.
主要方法:
- 特定无病原体的产卵母在生产高峰期间受到Mass IBV,DMV/1639 IBV或模拟感染的挑战.
- 在21天的时间里,监测了各种组织中的卵子产量,蛋质量,克洛亚克病毒分泌和病毒基因组负载.
- 评估了宏观和微观的病变,以及生殖和免疫组织中的亡指数.
主要成果:
- 感染DMV/1639IBV导致卵产量显著下降,形/软,以及卵腹膜炎.
- DMV/1639 IBV诱导了呼吸道,泌尿器官和免疫组织中的延长和更高的克洛亚克病毒分泌和更大的病毒基因组负载.
- 与Mass IBV和对照病毒相比,DMV/1639 IBV在多个器官 (包括脏,卵巢和卵管) 中引起显著更高的显微小损伤得分和亡指数.
结论:
- 与马萨诸塞州IBV基因型相比,Delmarva DMV/1639 IBV基因型在产母中表现出明显更高的致病性.
- DMV/1639 IBV对商业层的卵子生产和生殖健康构成重大威胁.
- 这些发现强调了监测和控制影响北美层行业的新兴IBV基因型的重要性.
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