1型糖尿病患者的身体组成和代谢综合征
Qiong Zeng1, Xiao-Jing Chen2, Yi-Ting He2
1Department of Neurology, The First Affiliated Hospital of Shantou University Medical College, Shantou 515041, Guangdong Province, China.
内脏脂肪,而不是BMI,更好地预测1型糖尿病 (T1DM) 的代谢综合征 (MS). 身体成分分析有助于确定T1DM患者的MS风险,即使是没有肥胖的人.
科学领域:
- 内分泌学 在内分泌学.
- 代谢障碍 代谢障碍 代谢障碍
- 糖尿病研究 糖尿病研究
背景情况:
- 在1型糖尿病 (T1DM) 患者中,肥胖和代谢综合征 (MS) 的患病率增加.
- 胰岛素耐药性是T1DM管理中日益关注的问题.
- 了解身体成分在T1DM并发症中的作用至关重要.
研究的目的:
- 评估T1DM患者的身体组成 (BC).
- 评估BC,MS和T1DM中的胰岛素抵抗之间的关系.
- 确定T1DM中MS和相关疾病的关键预测因素.
主要方法:
- 研究了101名T1DM患者 (年龄≥10年,疾病持续时间≥1年).
- 生物电阻分析 (BIA) 测量了身体组成参数.
- 使用估计的葡萄糖处置率 (eGDR) 评估胰岛素耐药性.
主要成果:
- 代谢综合征 (MS) 在15.84%的患者中被诊断出.
- 内脏脂肪指数 (VFI) 和干部脂肪质量与胰岛素抵抗 (eGDR) 有负相关性.
- VFI,eGDR和家族史预测了MS;eGDR和骨肌肉质量预测了高血压;体内脂肪和eGDR预测了脂质失调.
结论:
- 与BMI或腰部至部比率相比,内脏脂肪是T1DM中MS的优越预测因素.
- 身体成分分析,特别是干脂肪,有助于识别T1DM患者的MS风险,包括非肥胖个体.
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