化学疗法后B型肝炎表面抗体标位的变化在患有血液恶性瘤的患者中
Tülay Unver Ulusoy1,2, Pınar Tıglıoglu3, Hacer Demirköse4
1Department of Infectious Diseases and Clinical Microbiology, Ankara Etlik City Hospital, Ankara, TUR.
Cureus
|February 5, 2024
概括
在血液性恶性瘤患者的化疗后,乙型肝炎抗体标位下降. 预防预防可以防止乙型肝炎病毒的重新激活,这表明仅仅抗体水平无法预测风险.
科学领域:
- 在瘤学瘤学.
- 免疫学 免疫学 免疫学
- 传染性疾病 传染性疾病
背景情况:
- 血液性恶性瘤的化疗 (CT) 可以影响B型肝炎表面抗体 (抗HBs) 标位.
- 了解CT后的抗HBs变化和乙型肝炎病毒 (HBVr) 再激活是至关重要的.
研究的目的:
- 在血液恶性瘤患者CT后评估抗HBs标位变化.
- 评估该人群中HBVr的风险.
主要方法:
- 对接受CT (2013-2021) 的192名患者进行了回顾性研究.
- 对HBVr和抗HBs标位进行一年的随访.
- 对影响抗HBs变化的因素的分析.
主要成果:
- 在所有患者中观察到抗HBs标位的显著下降 (p=0.017).
- 抗乙肝核心抗体 (抗乙肝) 阳性患者和接受≥4次CT疗程 (p=0.025; p=0.041) 患者的抗乙肝核心抗体标位显著下降.
- 没有诊断出HBVr的病例,特别是在接受预防的患者中.
结论:
- 化疗会导致免疫抑制,导致抗HBs免疫力潜在下降或丧失.
- 以现行协议为指导的乙型肝炎病毒预防有效地预防HBVr.
- 在进行预防治疗时,化疗前的抗HBs标位或治疗后的抗HBs标位变化可能不是HBVr的显著风险因素.
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