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Updated: May 9, 2026

Preparation of Acute Hippocampal Slices from Rats and Transgenic Mice for the Study of Synaptic Alterations during Aging and Amyloid Pathology
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在APP/PS1小鼠中,长期的运动训练通过抑制海马NLRP3抑制炎症,从而抑制炎症

Xue Li1, Yu Jin1, Xianyi Ding1

  • 1School of Sports Medicine and Health, Chengdu Sport University, Chengdu, Sichuan, China.

Sports medicine and health science
|February 5, 2024
PubMed
概括

长期的体育炼通过减少神经炎症,改善了阿尔茨海默病 (AD) 的小鼠的认知能力. 运动降低了NLRP3和IL-1β等关键炎症因素的调节,保护海马神经元和记忆功能.

关键词:
在APP/PS1小鼠中.这是阿尔茨海默氏症.运动运动运动.在海马体内,海马体在NLRP3中,NLRP3是NLRP3中的一个.神经炎症是一种神经炎症.

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Long-term potentiation, or LTP, is one of the ways by which synaptic plasticity—changes in the strength of chemical synapses—can occur in the brain. LTP is the process of synaptic strengthening that occurs over time between pre- and postsynaptic neuronal connections. The synaptic strengthening of LTP works in opposition to the synaptic weakening of long-term depression (LTD) and together are the main mechanisms that underlie learning and memory.