胰岛素高分泌对口服葡萄糖的反应的未来心脏代谢影响:一项前性队列研究
Ravi Retnakaran1,2,3, Jiajie Pu1, Anthony J Hanley1,2,4
1Leadership Sinai Centre for Diabetes, Mount Sinai Hospital, Toronto, Canada.
EClinicalMedicine
|February 5, 2024
概括
一个强大的挑战后胰岛素反应表明良好的代谢健康,而不是不良的心脏代谢结果. 这种强大的胰岛素分泌反应预测了未来更好的代谢功能和降低糖尿病风险.
科学领域:
- 内分泌学 在内分泌学.
- 代谢健康 代谢健康
- 心血管疾病的风险
背景情况:
- 餐后高胰岛素血症对心脏代谢的影响尚不清楚,有相互矛盾的证据.
- 最近的研究表明,与代谢健康有有害和有益的关联.
研究的目的:
- 为了研究挑战后胰岛素分泌反应的纵向心脏代谢效应.
- 在4年的随访期内评估协会.
主要方法:
- 对306名孕妇进行前性队列研究,她们的产前葡萄糖耐受性各不相同.
- 连续的口服葡萄糖耐受性测试 (OGTT) 和心脏代谢风险因素评估在分娩后的1,3,5年.
- 在1年内使用修正胰岛素反应 (CIR) 评估胰岛素敏感性 (马苏达指数,HOMA-IR) 和β细胞功能 (ISSI-2,IGI/HOMA-IR).
主要成果:
- 较高的基线校正胰岛素响应 (CIR) 三分动物显示β细胞功能的逐步改善和更低的禁食/2小时葡萄糖水平.
- 更高的CIR独立地与更好的β细胞功能和3年和5年更低的葡萄糖水平有关.
- 一年内最高的CIR第三位预测了3年和5年的糖尿病或糖尿病前期的风险明显降低.
结论:
- 一个强大的挑战后胰岛素分泌反应与有利的代谢功能有关.
- 这种反应并不表明对心脏代谢健康有不良影响,并且可能预测未来的代谢益处.
- 需要对挑战后胰岛素反应的影响进行进一步的长期研究.
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