在患有基本高血压的成年人中,白质连接的改变
Weijie Chen1,2, Simin Deng3, Huali Jiang2
1Department of Cardiology, The Second School of Clinical Medicine, Southern Medical University, Guangdong, People's Republic of China.
International journal of general medicine
|February 5, 2024
概括
基本高血压 (EHT) 患者表现出改变的大脑网络拓,分离和整合受损. 身体质量指数 (BMI) 和体重与网络效率相关,这表明ETH中的潜在神经成像标志物.
科学领域:
- 神经成像是一种神经成像.
- 图形理论 图形理论
- 白色物质网络 白色物质网络
背景情况:
- 基本高血压 (EHT) 是一种普遍的心血管疾病.
- 了解EHT的神经基础对于开发有针对性的干预措施至关重要.
- 白质网络的改变可能在EHT的病理生理学中起作用.
研究的目的:
- 用图形理论研究基本高血压患者的白质网络拓学.
- 为了确定EHT患者和健康对照者之间大脑网络特征的差异.
主要方法:
- 横截面研究包括43名EHT患者和33名健康对照 (HC).
- 获取T1加权和扩散张力成像 (DTI) 数据.
- 使用图形理论构建结构性大脑网络,以分析全脑和节点特征.
主要成果:
- 在结构性网络中,EHT和HC两组都表现出了小世界性.
- 与HC相比,EHT组的小世界系数 (σ) 的曲线下面面积 (AUC) 更高,分类性 (assortativity) 的AUC更低.
- 在EHT患者中,在特定的前额区域 (右背侧上额头,左中侧上额头) 观察到节点聚类系数 (CP) 和局部效率 (Eloc) 的降低,其他前额区域 (左前带状和状) 的增加.
- 体重和体重指数 (BMI) 与 σ.正相关.
结论:
- 基本高血压与大脑网络分离和整合功能障碍有关.
- 前额叶皮层的结构连接性改变可能成为EHT的潜在神经成像标志物.
- 体重和BMI与EHT中的白质网络效率有关.
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