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PLGA-智能生物相容聚合物:动力降解研究和活性原理释放研究

Maria-Viorica Ciocîlteu¹, Rău Gabriela¹, Manuel Ovidiu Amzoiu¹

¹University of Medicine and Pharmacy of Craiova, Petru Rareș Street 2, 200349 Craiova, Romania.

Current health sciences journal

|February 5, 2024

概括

这项研究开发了用于治疗剂持续释放的新型聚乳糖合糖酸 (PLGA) 输送系统. 这些系统提供长时间的药物水平,避免各种治疗的毒性.

科学领域:

生物材料科学生物材料科学
药物输送系统药物输送系统
聚合物化学聚合物化学

背景情况:

传统的药物管理在维持治疗水平和患者遵守方面面临挑战.
需要为各种治疗剂提供先进的输送系统,包括治疗骨疾病,癌症和炎症的治疗剂.

研究的目的:

开发使用聚乳糖合糖酸 (PLGA) 的长时间药物递送系统.
为了达到活性成分在最低抑制度以上的持续治疗水平.
为传统药物给药途径提供更安全的替代品.

主要方法:

使用的多乳酸-同-甘油酸 (PLGA) 具有65:35的乳酸 (LA):甘油酸 (GA) 共聚合物比率.
在酸盐缓冲盐水 (PBS) 中研究PLGA降解,观察水解和自水解.
由扩散和聚合物侵蚀影响的特征活性原理释放动力学.

主要成果:

在PBS中,PLGA通过同时水解和自水解在约40天内完全降解.
活性成分的释放发生在35天内,由聚合物基质的扩散驱动.
释放特征表明可能存在持续的治疗药物水平.

结论:

PLGA (65:35 LA:GA) 是一种可行的生物降解材料,用于开发长时间的药物输送系统.
这些系统可以长时间保持治疗药物度.
开发的PLGA系统为各种治疗应用提供了传统管理的有希望的替代方案.

关键词:

在 PLGA PLGA 中.生物相容性的生物相容性动力学研究动力学研究释放释放释放释放释放

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