计量化学疗法和药物再利用:瘤学的范式转变
Nusrat Jan1, Shazia Sofi1, Hina Qayoom1
1Department of Bioresources, School of Biological Sciences, University of Kashmir, Srinagar-190006, India.
Heliyon
|February 5, 2024
概括
计量化学疗法 (MCT) 和药物重用结合在一起形成一种形式.
科学领域:
- 在瘤学瘤学.
- 药理学 药理学是指药理学的学科.
- 药物发现 药物发现 药物发现
背景情况:
- 癌症对全球健康和经济构成重大挑战,传统化疗往往受到毒性和不完全根除的限制.
- 计量化学疗法 (MCT) 提供了一种新的剂量计划,可以减少副作用并改善疾病管理.
- 药物重定向通过利用已知安全性概况的现有药物来加速癌症治疗的发展.
研究的目的:
- 审查计量化学疗法和药物重新定位的综合益处,称为"计量学",用于癌症治疗.
- 突出计量学在改善患者治疗结果,减少毒性和提高可负担性方面的潜力,特别是在资源有限的环境中.
- 检查计量学在乳腺癌管理中的应用和有效性.
主要方法:
- 对癌症中计量化学疗法和药物重定位的临床前和临床研究的审查.
- 分析"计量学"方法,整合MCT和重用药物.
- 专注于乳腺癌作为计量学应用的案例研究.
主要成果:
- 计量学结合了降低的毒性,口服的潜力和改善的生活质量.
- 临床研究支持MCT的疗效,但副作用是可以忍受的.
- 对乳腺癌中的计量学有希望的临床前和临床结果.
结论:
- 计量化学疗法与药物重新定位相结合,为癌症管理提供了一个有希望的,负担得起的和可访问的方法.
- 计量学策略与传统化疗相比具有显著的优势,特别是在乳腺癌中.
- 需要进行进一步的临床研究,以巩固计量学在全面癌症治疗中的作用.
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