由于人类乳头瘤病毒疫苗接种导致的急性管间膜性炎
Sachiko Nakaoka1, Shinichi Tsubata1, Yuichi Adachi2
1Department of Pediatrics, Toyama Red Cross Hospital, Toyama, Japan.
JMA journal
|February 5, 2024
概括
在HPV疫苗接种后,在一个青少年身上观察到急性管间性炎 (ATIN) 和类似MERS的脑病变. 这一案例凸显了疫苗的潜在不良影响,需要医生保持警.
科学领域:
- 儿科 儿科 儿科
- 腎臟病學 (nephrology) 是一種醫學專業.
- 神经学 神经学
- 免疫学 免疫学 免疫学
背景情况:
- 急性管间炎 (ATIN) 是儿童急性损伤的罕见原因.
- 轻度脑炎/带有可逆损伤的脑病变 (MERS) 是一种神经疾病,具有特征性的MRI发现.
- 人类乳头瘤病毒 (HPV) 疫苗接种对于预防宫癌至关重要.
研究的目的:
- 在儿科患者中报告一个ATIN病例与MERS类似的发现.
- 调查HPV疫苗接种与ATIN和MERS类病变的发展之间的潜在关联.
- 提高医疗保健提供者对HPV疫苗接种潜在不良影响的认识.
主要方法:
- 一个14岁女孩患有反复发烧的案例介绍.
- 实验室检测包括CRP,ESR,尿液N-乙-β-D-葡萄糖胺酶和β-2-微球蛋白.
- 脏扫描和头部MRI,以评估脏和大脑的异常.
- 审查患者的疫苗接种史和与症状发作的时间相关性.
主要成果:
- 该患者出现了反复高烧,炎症标志物 (CRP,ESR) 和生物标志物表明ATIN的升高.
- 头部MRI显示了没有其他神经症状的MERS类病变.
- 发烧发作的出现与HPV疫苗接种 (第二剂和第三剂) 暂时相关.
结论:
- 本案例表明HPV疫苗接种与ATIN和MERS类病变的发展之间存在潜在的关联.
- 医生应保持与HPV疫苗接种相关的潜在不良影响的认识.
- 可能需要进一步的研究来探索将HPV疫苗接种与这些疾病联系在一起的免疫机制.
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